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Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways.
Andrianifahanana M, Hernandez DM, Yin X, Kang JH, Jung MY, Wang Y, Yi ES, Roden AC, Limper AH, Leof EB. Andrianifahanana M, et al. Among authors: yin x. FASEB J. 2016 Nov;30(11):3733-3744. doi: 10.1096/fj.201600428R. Epub 2016 Aug 1. FASEB J. 2016. PMID: 27480571 Free PMC article.
These findings provide new perspectives on the interrelation of metabolism and profibrotic TGF-beta signaling and present opportunities for potential therapeutic intervention.-Andrianifahanana, M., Hernandez, D. M., Yin, X., Kang, J.-H., Jung, M.-Y., Wang, Y., Yi, E …
These findings provide new perspectives on the interrelation of metabolism and profibrotic TGF-beta signaling and present opportunities for …
Fatty acid synthase is required for profibrotic TGF-β signaling.
Jung MY, Kang JH, Hernandez DM, Yin X, Andrianifahanana M, Wang Y, Gonzalez-Guerrico A, Limper AH, Lupu R, Leof EB. Jung MY, et al. Among authors: yin x. FASEB J. 2018 Jul;32(7):3803-3815. doi: 10.1096/fj.201701187R. Epub 2018 Feb 16. FASEB J. 2018. PMID: 29475397 Free PMC article.
Remarkably, inhibition of FASN not only decreased expression of profibrotic targets, but lung function was also stabilized/improved, as assessed by peripheral blood oxygenation.-Jung, M.-Y., Kang, J.-H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., Gon …
Remarkably, inhibition of FASN not only decreased expression of profibrotic targets, but lung function was also stabilized/improved, as asse …
IPF pathogenesis is dependent upon TGFβ induction of IGF-1.
Hernandez DM, Kang JH, Choudhury M, Andrianifahanana M, Yin X, Limper AH, Leof EB. Hernandez DM, et al. Among authors: yin x. FASEB J. 2020 Apr;34(4):5363-5388. doi: 10.1096/fj.201901719RR. Epub 2020 Feb 17. FASEB J. 2020. PMID: 32067272 Free PMC article.
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