Fatty acid synthase is required for profibrotic TGF-β signaling.
Jung MY, Kang JH, Hernandez DM, Yin X, Andrianifahanana M, Wang Y, Gonzalez-Guerrico A, Limper AH, Lupu R, Leof EB.
Jung MY, et al. Among authors: yin x.
FASEB J. 2018 Jul;32(7):3803-3815. doi: 10.1096/fj.201701187R. Epub 2018 Feb 16.
FASEB J. 2018.
PMID: 29475397
Free PMC article.
Remarkably, inhibition of FASN not only decreased expression of profibrotic targets, but lung function was also stabilized/improved, as assessed by peripheral blood oxygenation.-Jung, M.-Y., Kang, J.-H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., Gon …
Remarkably, inhibition of FASN not only decreased expression of profibrotic targets, but lung function was also stabilized/improved, as asse …