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HYPOTHesizing about central comBAT against obesity.
González-García I, Milbank E, Martinez-Ordoñez A, Diéguez C, López M, Contreras C. González-García I, et al. J Physiol Biochem. 2020 May;76(2):193-211. doi: 10.1007/s13105-019-00719-y. Epub 2019 Dec 16. J Physiol Biochem. 2020. PMID: 31845114 Review.
Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK.
Martínez de Morentin PB, González-García I, Martins L, Lage R, Fernández-Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena-Sempere M, López M. Martínez de Morentin PB, et al. Cell Metab. 2014 Jul 1;20(1):41-53. doi: 10.1016/j.cmet.2014.03.031. Epub 2014 May 22. Cell Metab. 2014. PMID: 24856932 Free PMC article.
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance.
Contreras C, González-García I, Martínez-Sánchez N, Seoane-Collazo P, Jacas J, Morgan DA, Serra D, Gallego R, Gonzalez F, Casals N, Nogueiras R, Rahmouni K, Diéguez C, López M. Contreras C, et al. Cell Rep. 2014 Oct 9;9(1):366-377. doi: 10.1016/j.celrep.2014.08.057. Epub 2014 Oct 2. Cell Rep. 2014. PMID: 25284795 Free PMC article.
Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats.
Martínez de Morentin PB, Lage R, González-García I, Ruíz-Pino F, Martins L, Fernández-Mallo D, Gallego R, Fernø J, Señarís R, Saha AK, Tovar S, Diéguez C, Nogueiras R, Tena-Sempere M, López M. Martínez de Morentin PB, et al. Endocrinology. 2015 Mar;156(3):947-60. doi: 10.1210/en.2014-1611. Epub 2014 Dec 23. Endocrinology. 2015. PMID: 25535827 Free PMC article.
Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.
Ortega-Molina A, Lopez-Guadamillas E, Mattison JA, Mitchell SJ, Muñoz-Martin M, Iglesias G, Gutierrez VM, Vaughan KL, Szarowicz MD, González-García I, López M, Cebrián D, Martinez S, Pastor J, de Cabo R, Serrano M. Ortega-Molina A, et al. Cell Metab. 2015 Apr 7;21(4):558-70. doi: 10.1016/j.cmet.2015.02.017. Epub 2015 Mar 26. Cell Metab. 2015. PMID: 25817535 Free PMC article.
A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.
Martins L, Seoane-Collazo P, Contreras C, González-García I, Martínez-Sánchez N, González F, Zalvide J, Gallego R, Diéguez C, Nogueiras R, Tena-Sempere M, López M. Martins L, et al. Cell Rep. 2016 Aug 23;16(8):2231-2242. doi: 10.1016/j.celrep.2016.07.045. Epub 2016 Aug 11. Cell Rep. 2016. PMID: 27524625 Free PMC article.
Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance.
González-García I, Fernø J, Diéguez C, Nogueiras R, López M. González-García I, et al. Neuroendocrinology. 2017;104(4):398-411. doi: 10.1159/000448432. Epub 2016 Oct 11. Neuroendocrinology. 2017. PMID: 27728904 Free article. Review.
UCP1 and T3: A key "(un)couple" in energy balance.
González-García I, López M. González-García I, et al. Temperature (Austin). 2016 Aug 5;4(1):18-20. doi: 10.1080/23328940.2016.1220351. eCollection 2017. Temperature (Austin). 2016. PMID: 28349091 Free PMC article. No abstract available.
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.
Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Martínez-Sánchez N, et al. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014. Cell Metab. 2017. PMID: 28683288 Free PMC article.
102 results