Frock RL - Search Results

1

Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking.

Chen X, Tasca F, Wang Q, Liu J, Janssen JM, Brescia MD, Bellin M, Szuhai K, Kenrick J, Frock RL, Gonçalves MAFV. Chen X, et al. Among authors: frock rl. Nucleic Acids Res. 2020 Jan 24;48(2):974-995. doi: 10.1093/nar/gkz1121. Nucleic Acids Res. 2020. PMID: 31799604 Free PMC article.

2

Precise and broad scope genome editing based on high-specificity Cas9 nickases.

Wang Q, Liu J, Janssen JM, Le Bouteiller M, Frock RL, Gonçalves MAFV. Wang Q, et al. Among authors: frock rl. Nucleic Acids Res. 2021 Jan 25;49(2):1173-1198. doi: 10.1093/nar/gkaa1236. Nucleic Acids Res. 2021. PMID: 33398349 Free PMC article.

3

Ku70 suppresses alternative end joining in G1-arrested progenitor B cells.

Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL. Liang Z, et al. Among authors: frock rl. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2103630118. doi: 10.1073/pnas.2103630118. Proc Natl Acad Sci U S A. 2021. PMID: 34006647 Free PMC article.

4

Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease.

Lattanzi A, Camarena J, Lahiri P, Segal H, Srifa W, Vakulskas CA, Frock RL, Kenrick J, Lee C, Talbott N, Skowronski J, Cromer MK, Charlesworth CT, Bak RO, Mantri S, Bao G, DiGiusto D, Tisdale J, Wright JF, Bhatia N, Roncarolo MG, Dever DP, Porteus MH. Lattanzi A, et al. Among authors: frock rl. Sci Transl Med. 2021 Jun 16;13(598):eabf2444. doi: 10.1126/scitranslmed.abf2444. Sci Transl Med. 2021. PMID: 34135108 Free PMC article.

5

DNA-PKcs suppresses illegitimate chromosome rearrangements.

Wang J, Sadeghi CA, Frock RL. Wang J, et al. Among authors: frock rl. Nucleic Acids Res. 2024 May 22;52(9):5048-5066. doi: 10.1093/nar/gkae140. Nucleic Acids Res. 2024. PMID: 38412274 Free PMC article.

6

Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing.

Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Upadhyayula S, Gutierrez-Martinez P, Ebina W, Fasth A, Kirchhausen T, Talkowski ME, Agarwal S, Alt FW, Rossi DJ. Paulsen BS, et al. Among authors: frock rl. Nat Biomed Eng. 2017 Nov;1(11):878-888. doi: 10.1038/s41551-017-0145-2. Epub 2017 Oct 9. Nat Biomed Eng. 2017. PMID: 31015609 Free PMC article.

7

DNA End Joining: G0-ing to the Core.

Frock RL, Sadeghi C, Meng J, Wang JL. Frock RL, et al. Biomolecules. 2021 Oct 9;11(10):1487. doi: 10.3390/biom11101487. Biomolecules. 2021. PMID: 34680120 Free PMC article. Review.

8

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW. Frock RL, et al. Nat Biotechnol. 2015 Feb;33(2):179-86. doi: 10.1038/nbt.3101. Epub 2014 Dec 15. Nat Biotechnol. 2015. PMID: 25503383 Free PMC article.

9

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.

Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK. Johnson BR, et al. Among authors: frock rl. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9677-82. doi: 10.1073/pnas.0403250101. Epub 2004 Jun 21. Proc Natl Acad Sci U S A. 2004. PMID: 15210943 Free PMC article.

10

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW. Chiarle R, et al. Among authors: frock rl. Cell. 2011 Sep 30;147(1):107-19. doi: 10.1016/j.cell.2011.07.049. Cell. 2011. PMID: 21962511 Free PMC article.

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