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Crispr/Cas9 homologous recombination (HR).
Bellin M. Bellin M. Drug Discov Today Technol. 2018 Aug;28:1-2. doi: 10.1016/j.ddtec.2018.08.006. Drug Discov Today Technol. 2018. PMID: 30205875 No abstract available.
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.
Qiao X, van der Zanden SY, Wander DPA, Borràs DM, Song JY, Li X, van Duikeren S, van Gils N, Rutten A, van Herwaarden T, van Tellingen O, Giacomelli E, Bellin M, Orlova V, Tertoolen LGJ, Gerhardt S, Akkermans JJ, Bakker JM, Zuur CL, Pang B, Smits AM, Mummery CL, Smit L, Arens R, Li J, Overkleeft HS, Neefjes J. Qiao X, et al. Among authors: bellin m. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15182-15192. doi: 10.1073/pnas.1922072117. Epub 2020 Jun 17. Proc Natl Acad Sci U S A. 2020. PMID: 32554494 Free PMC article.
Generation of human induced pluripotent stem cell line LUMCi027-A and its isogenic gene-corrected line from a patient affected by arrhythmogenic cardiomyopathy and carrying the c.2013delC PKP2 mutation.
Meraviglia V, Arendzen CH, Tok M, Freund C, Maione AS, Sommariva E, Bellin M. Meraviglia V, et al. Among authors: bellin m. Stem Cell Res. 2020 Jul;46:101835. doi: 10.1016/j.scr.2020.101835. Epub 2020 May 5. Stem Cell Res. 2020. PMID: 32485643 Free article.
Generation of two human induced pluripotent stem cell lines, LUMCi020-A and LUMCi021-A, from two patients with Catecholaminergic Polymorphic Ventricular Tachycardia carrying heterozygous mutations in the RYR2 gene.
Meraviglia V, Arendzen CH, Freund C, Atsma DE, Mummery CL, Bellin M. Meraviglia V, et al. Among authors: bellin m. Stem Cell Res. 2020 May;45:101764. doi: 10.1016/j.scr.2020.101764. Epub 2020 Apr 8. Stem Cell Res. 2020. PMID: 32315959 Free article.
Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia.
Campostrini G, Kosmidis G, Ward-van Oostwaard D, Davis RP, Yiangou L, Ottaviani D, Veerman CC, Mei H, Orlova VV, Wilde AAM, Bezzina CR, Verkerk AO, Mummery CL, Bellin M. Campostrini G, et al. Among authors: bellin m. Cardiovasc Res. 2023 Mar 17;119(1):167-182. doi: 10.1093/cvr/cvac059. Cardiovasc Res. 2023. PMID: 35394010 Free PMC article.
547 results