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Allosteric regulation of proteases.
Hauske P, Ottmann C, Meltzer M, Ehrmann M, Kaiser M. Hauske P, et al. Among authors: ottmann c. Chembiochem. 2008 Dec 15;9(18):2920-8. doi: 10.1002/cbic.200800528. Chembiochem. 2008. PMID: 19021141 Review.
Molecular tweezers modulate 14-3-3 protein-protein interactions.
Bier D, Rose R, Bravo-Rodriguez K, Bartel M, Ramirez-Anguita JM, Dutt S, Wilch C, Klärner FG, Sanchez-Garcia E, Schrader T, Ottmann C. Bier D, et al. Among authors: ottmann c. Nat Chem. 2013 Mar;5(3):234-9. doi: 10.1038/nchem.1570. Epub 2013 Feb 17. Nat Chem. 2013. PMID: 23422566
Stabilizer-Guided Inhibition of Protein-Protein Interactions.
Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C. Milroy LG, et al. Among authors: ottmann c. Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15720-4. doi: 10.1002/anie.201507976. Epub 2015 Nov 5. Angew Chem Int Ed Engl. 2015. PMID: 26537010
Structural interface between LRRK2 and 14-3-3 protein.
Stevers LM, de Vries RM, Doveston RG, Milroy LG, Brunsveld L, Ottmann C. Stevers LM, et al. Among authors: ottmann c. Biochem J. 2017 Mar 23;474(7):1273-1287. doi: 10.1042/BCJ20161078. Biochem J. 2017. PMID: 28202711
Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
Doveston RG, Kuusk A, Andrei SA, Leysen S, Cao Q, Castaldi MP, Hendricks A, Brunsveld L, Chen H, Boyd H, Ottmann C. Doveston RG, et al. Among authors: ottmann c. FEBS Lett. 2017 Aug;591(16):2449-2457. doi: 10.1002/1873-3468.12723. Epub 2017 Aug 6. FEBS Lett. 2017. PMID: 28640363 Free article.
172 results