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Sustained exposure to the DNA demethylating agent, 2'-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy.
Schnekenburger M, Grandjenette C, Ghelfi J, Karius T, Foliguet B, Dicato M, Diederich M. Schnekenburger M, et al. Among authors: grandjenette c. Biochem Pharmacol. 2011 Feb 1;81(3):364-78. doi: 10.1016/j.bcp.2010.10.013. Epub 2010 Oct 31. Biochem Pharmacol. 2011. PMID: 21044612
Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr-Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells.
Trécul A, Morceau F, Gaigneaux A, Orsini M, Chateauvieux S, Grandjenette C, Dicato M, Diederich M. Trécul A, et al. Among authors: grandjenette c. Cancer Lett. 2013 Oct 28;340(1):30-42. doi: 10.1016/j.canlet.2013.06.023. Epub 2013 Jun 26. Cancer Lett. 2013. PMID: 23811288
Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells.
Florean C, Schnekenburger M, Lee JY, Kim KR, Mazumder A, Song S, Kim JM, Grandjenette C, Kim JG, Yoon AY, Dicato M, Kim KW, Christov C, Han BW, Proksch P, Diederich M. Florean C, et al. Among authors: grandjenette c. Oncotarget. 2016 Apr 26;7(17):24027-49. doi: 10.18632/oncotarget.8210. Oncotarget. 2016. PMID: 27006469 Free PMC article.
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