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Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas.
Ruiz-Rodado V, Malta TM, Seki T, Lita A, Dowdy T, Celiku O, Cavazos-Saldana A, Li A, Liu Y, Han S, Zhang W, Song H, Davis D, Lee S, Trepel JB, Sabedot TS, Munasinghe J, Yang C, Herold-Mende C, Gilbert MR, Cherukuri MK, Noushmehr H, Larion M. Ruiz-Rodado V, et al. Among authors: celiku o. Neuro Oncol. 2020 Apr 15;22(4):480-492. doi: 10.1093/neuonc/noz207. Neuro Oncol. 2020. PMID: 31665443 Free PMC article.
Novel Targeting of Transcription and Metabolism in Glioblastoma.
Su YT, Chen R, Wang H, Song H, Zhang Q, Chen LY, Lappin H, Vasconcelos G, Lita A, Maric D, Li A, Celiku O, Zhang W, Meetze K, Estok T, Larion M, Abu-Asab M, Zhuang Z, Yang C, Gilbert MR, Wu J. Su YT, et al. Among authors: celiku o. Clin Cancer Res. 2018 Mar 1;24(5):1124-1137. doi: 10.1158/1078-0432.CCR-17-2032. Epub 2017 Dec 18. Clin Cancer Res. 2018. PMID: 29254993 Free PMC article.
Targeting IDH1-Mutated Malignancies with NRF2 Blockade.
Liu Y, Lu Y, Celiku O, Li A, Wu Q, Zhou Y, Yang C. Liu Y, et al. Among authors: celiku o. J Natl Cancer Inst. 2019 Oct 1;111(10):1033-1041. doi: 10.1093/jnci/djy230. J Natl Cancer Inst. 2019. PMID: 30759236 Free PMC article.
Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma.
Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR, Park DM. Jung J, et al. Among authors: celiku o. Cancer Res. 2019 Oct 15;79(20):5218-5232. doi: 10.1158/0008-5472.CAN-19-0198. Epub 2019 Sep 5. Cancer Res. 2019. PMID: 31488423 Free PMC article.
Proceedings of the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) Adult Medulloblastoma Workshop.
Penas-Prado M, Theeler BJ, Cordeiro B, Dunkel IJ, Hau P, Mahajan A, Robinson GW, Willmarth N, Aboud O, Aldape K, Butman JA, Gajjar A, Kelly W, Rao G, Raygada M, Siegel C, Romo CG, Armstrong TS, Gilbert MR; NCI-CONNECT Adult Medulloblastoma Workshop. Penas-Prado M, et al. Neurooncol Adv. 2020 Aug 17;2(1):vdaa097. doi: 10.1093/noajnl/vdaa097. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 33005896 Free PMC article. Review.
Sphingolipid Pathway as a Source of Vulnerability in IDH1mut Glioma.
Dowdy T, Zhang L, Celiku O, Movva S, Lita A, Ruiz-Rodado V, Gilbert MR, Larion M. Dowdy T, et al. Among authors: celiku o. Cancers (Basel). 2020 Oct 10;12(10):2910. doi: 10.3390/cancers12102910. Cancers (Basel). 2020. PMID: 33050528 Free PMC article.
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
Ruiz-Rodado V, Lita A, Dowdy T, Celiku O, Saldana AC, Wang H, Yang CZ, Chari R, Li A, Zhang W, Song H, Zhang M, Ahn S, Davis D, Chen X, Zhuang Z, Herold-Mende C, Walters KJ, Gilbert MR, Larion M. Ruiz-Rodado V, et al. Among authors: celiku o. Cancer Metab. 2020 Oct 21;8:23. doi: 10.1186/s40170-020-00229-2. eCollection 2020. Cancer Metab. 2020. PMID: 33101674 Free PMC article.
IDH1 mutations induce organelle defects via dysregulated phospholipids.
Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M. Lita A, et al. Among authors: celiku o. Nat Commun. 2021 Jan 27;12(1):614. doi: 10.1038/s41467-020-20752-6. Nat Commun. 2021. PMID: 33504762 Free PMC article.
27 results