Chern JH - Search Results

1

A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses.

Yang CC, Hu HS, Lin HM, Wu PS, Wu RH, Tian JN, Wu SH, Tsou LK, Song JS, Chen HW, Chern JH, Chen CT, Yueh A. Yang CC, et al. Among authors: chern jh. Antiviral Res. 2019 Dec;172:104636. doi: 10.1016/j.antiviral.2019.104636. Epub 2019 Oct 23. Antiviral Res. 2019. PMID: 31654671

2

Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay.

Yang CC, Hsieh YC, Lee SJ, Wu SH, Liao CL, Tsao CH, Chao YS, Chern JH, Wu CP, Yueh A. Yang CC, et al. Among authors: chern jh. Antimicrob Agents Chemother. 2011 Jan;55(1):229-38. doi: 10.1128/AAC.00855-10. Epub 2010 Oct 11. Antimicrob Agents Chemother. 2011. PMID: 20937790 Free PMC article.

3

Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor.

Lin HM, Wang JC, Hu HS, Wu PS, Yang CC, Wu CP, Pu SY, Hsu TA, Jiaang WT, Chao YS, Chern JH, Yeh TK, Yueh A. Lin HM, et al. Among authors: chern jh. Antimicrob Agents Chemother. 2012 Jan;56(1):44-53. doi: 10.1128/AAC.00599-11. Epub 2011 Oct 17. Antimicrob Agents Chemother. 2012. PMID: 22006008 Free PMC article.

4

A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease.

Yang CC, Hu HS, Wu RH, Wu SH, Lee SJ, Jiaang WT, Chern JH, Huang ZS, Wu HN, Chang CM, Yueh A. Yang CC, et al. Among authors: chern jh. Antimicrob Agents Chemother. 2014;58(1):110-9. doi: 10.1128/AAC.01281-13. Epub 2013 Oct 21. Antimicrob Agents Chemother. 2014. PMID: 24145533 Free PMC article.

5

Resistance studies of a dithiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems.

Lin HM, Wang JC, Hu HS, Wu PS, Wang WH, Wu SY, Yang CC, Yeh TK, Hsu TA, Jiaang WT, Chao YS, Chern JH, Yueh A. Lin HM, et al. Among authors: chern jh. Antimicrob Agents Chemother. 2013 Feb;57(2):723-33. doi: 10.1128/AAC.01403-12. Epub 2012 Nov 19. Antimicrob Agents Chemother. 2013. PMID: 23165461 Free PMC article.

6

A Potent, Selective, and Orally Bioavailable HCV NS5A Inhibitor for Treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazol-2-yl)pyrrolidine-2-carboxamide.

Kang IJ, Hsu SJ, Yang HY, Yeh TK, Lee CC, Lee YC, Tian YW, Song JS, Hsu TA, Chao YS, Yueh A, Chern JH. Kang IJ, et al. Among authors: chern jh. J Med Chem. 2017 Jan 12;60(1):228-247. doi: 10.1021/acs.jmedchem.6b00962. Epub 2016 Dec 28. J Med Chem. 2017. PMID: 27966956

7

Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments.

Wu RH, Tsai MH, Tsai KN, Tian JN, Wu JS, Wu SY, Chern JH, Chen CH, Yueh A. Wu RH, et al. Among authors: chern jh. J Virol. 2017 May 26;91(12):e01836-16. doi: 10.1128/JVI.01836-16. Print 2017 Jun 15. J Virol. 2017. PMID: 28381578 Free PMC article.

8

Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication.

Lin HM, Wu PS, Hu HS, Chang WC, Wu RH, Tian JN, Chern JH, Yueh A. Lin HM, et al. Among authors: chern jh. J Virol Methods. 2018 Sep;259:10-17. doi: 10.1016/j.jviromet.2018.05.010. Epub 2018 May 18. J Virol Methods. 2018. PMID: 29782889

9

A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus.

Yeh TK, Kang IJ, Hsu TA, Lee YC, Lee CC, Hsu SJ, Tian YW, Yang HY, Chen CT, Chao YS, Yueh A, Chern JH. Yeh TK, et al. Among authors: chern jh. Eur J Med Chem. 2019 Apr 1;167:245-268. doi: 10.1016/j.ejmech.2019.02.016. Epub 2019 Feb 6. Eur J Med Chem. 2019. PMID: 30772607

10

Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors.

Kang IJ, Wang LW, Hsu SJ, Lee CC, Lee YC, Wu YS, Yueh A, Wang JC, Hsu TA, Chao YS, Chern JH. Kang IJ, et al. Among authors: chern jh. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6063-8. doi: 10.1016/j.bmcl.2009.09.037. Epub 2009 Sep 17. Bioorg Med Chem Lett. 2009. PMID: 19796940

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