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Page 1
A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids.
Aguilera E, Perdomo C, Espindola A, Corvo I, Faral-Tello P, Robello C, Serna E, Benítez F, Riveros R, Torres S, Vera de Bilbao NI, Yaluff G, Alvarez G. Aguilera E, et al. Among authors: alvarez g. Molecules. 2019 Oct 22;24(20):3800. doi: 10.3390/molecules24203800. Molecules. 2019. PMID: 31652542 Free PMC article.
1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition.
Alvarez G, Aguirre-López B, Cabrera N, Marins EB, Tinoco L, Batthyány CI, de Gómez-Puyou MT, Puyou AG, Pérez-Montfort R, Cerecetto H, González M. Alvarez G, et al. J Enzyme Inhib Med Chem. 2013 Oct;28(5):981-9. doi: 10.3109/14756366.2012.700928. Epub 2012 Jul 18. J Enzyme Inhib Med Chem. 2013. PMID: 22803666
Trypanosoma cruzi chemical proteomics using immobilized benznidazole.
Trochine A, Alvarez G, Corre S, Faral-Tello P, Durán R, Batthyany CI, Cerecetto H, González M, Robello C. Trochine A, et al. Among authors: alvarez g. Exp Parasitol. 2014 May;140:33-8. doi: 10.1016/j.exppara.2014.03.013. Epub 2014 Mar 13. Exp Parasitol. 2014. PMID: 24632192
Identification of a new amide-containing thiazole as a drug candidate for treatment of Chagas' disease.
Álvarez G, Varela J, Cruces E, Fernández M, Gabay M, Leal SM, Escobar P, Sanabria L, Serna E, Torres S, Figueredo Thiel SJ, Yaluff G, Vera de Bilbao NI, Cerecetto H, González M. Álvarez G, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1398-404. doi: 10.1128/AAC.03814-14. Epub 2014 Dec 15. Antimicrob Agents Chemother. 2015. PMID: 25512408 Free PMC article.
Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo.
Álvarez G, Martínez J, Varela J, Birriel E, Cruces E, Gabay M, Leal SM, Escobar P, Aguirre-López B, Cabrera N, Tuena de Gómez-Puyou M, Gómez Puyou A, Pérez-Montfort R, Yaluff G, Torres S, Serna E, Vera de Bilbao N, González M, Cerecetto H. Álvarez G, et al. Eur J Med Chem. 2015 Jul 15;100:246-56. doi: 10.1016/j.ejmech.2015.06.018. Epub 2015 Jun 12. Eur J Med Chem. 2015. PMID: 26094151
3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies.
Couto M, Sánchez C, Dávila B, Machín V, Varela J, Álvarez G, Cabrera M, Celano L, Aguirre-López B, Cabrera N, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Cerecetto H, González M. Couto M, et al. Among authors: alvarez g. Molecules. 2015 Aug 12;20(8):14595-610. doi: 10.3390/molecules200814595. Molecules. 2015. PMID: 26274947 Free PMC article.
Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.
Aguilera E, Varela J, Birriel E, Serna E, Torres S, Yaluff G, de Bilbao NV, Aguirre-López B, Cabrera N, Díaz Mazariegos S, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Minini L, Merlino A, Cerecetto H, González M, Alvarez G. Aguilera E, et al. Among authors: alvarez g. ChemMedChem. 2016 Jun 20;11(12):1328-38. doi: 10.1002/cmdc.201500385. Epub 2015 Oct 23. ChemMedChem. 2016. PMID: 26492824
812 results