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Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.
Chatzopoulou M, Claridge TDW, Davies KE, Davies SG, Elsey DJ, Emer E, Fletcher AM, Harriman S, Robinson N, Rowley JA, Russell AJ, Tinsley JM, Weaver R, Wilkinson IVL, Willis NJ, Wilson FX, Wynne GM. Chatzopoulou M, et al. Among authors: wilkinson ivl. J Med Chem. 2020 Mar 12;63(5):2547-2556. doi: 10.1021/acs.jmedchem.9b01547. Epub 2019 Oct 25. J Med Chem. 2020. PMID: 31599580
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
Wilkinson IVL, Perkins KJ, Dugdale H, Moir L, Vuorinen A, Chatzopoulou M, Squire SE, Monecke S, Lomow A, Geese M, Charles PD, Burch P, Tinsley JM, Wynne GM, Davies SG, Wilson FX, Rastinejad F, Mohammed S, Davies KE, Russell AJ. Wilkinson IVL, et al. Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2420-2428. doi: 10.1002/anie.201912392. Epub 2020 Jan 3. Angew Chem Int Ed Engl. 2020. PMID: 31755636 Free PMC article.
Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.
Vuorinen A, Wilkinson IVL, Chatzopoulou M, Edwards B, Squire SE, Fairclough RJ, Bazan NA, Milner JA, Conole D, Donald JR, Shah N, Willis NJ, Martínez RF, Wilson FX, Wynne GM, Davies SG, Davies KE, Russell AJ. Vuorinen A, et al. Among authors: wilkinson ivl. Eur J Med Chem. 2021 Aug 5;220:113431. doi: 10.1016/j.ejmech.2021.113431. Epub 2021 Apr 20. Eur J Med Chem. 2021. PMID: 33915371
From diagnosis to therapy in Duchenne muscular dystrophy.
Babbs A, Chatzopoulou M, Edwards B, Squire SE, Wilkinson IVL, Wynne GM, Russell AJ, Davies KE. Babbs A, et al. Among authors: wilkinson ivl. Biochem Soc Trans. 2020 Jun 30;48(3):813-821. doi: 10.1042/BST20190282. Biochem Soc Trans. 2020. PMID: 32597486 Free PMC article. Review.
Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.
Quevedo CE, Bataille CJR, Byrne S, Durbin M, Elkins J, Guillermo A, Jones AM, Knapp S, Nadali A, Walker RG, Wilkinson IVL, Wynne GM, Davies SG, Russell AJ. Quevedo CE, et al. Among authors: wilkinson ivl. Bioorg Med Chem. 2020 Nov 15;28(22):115724. doi: 10.1016/j.bmc.2020.115724. Epub 2020 Aug 26. Bioorg Med Chem. 2020. PMID: 33128909
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.
Jackson TR, Vuorinen A, Josa-Culleré L, Madden KS, Conole D, Cogswell TJ, Wilkinson IVL, Kettyle LM, Zhang D, O'Mahony A, Gracias D, McCall L, Westwood R, Terstappen GC, Davies SG, Tate EW, Wynne GM, Vyas P, Russell AJ, Milne TA. Jackson TR, et al. Among authors: wilkinson ivl. iScience. 2022 Jul 19;25(8):104787. doi: 10.1016/j.isci.2022.104787. eCollection 2022 Aug 19. iScience. 2022. PMID: 35992086 Free PMC article.
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