Vidal P - Search Results

1

Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor.

Hao J, Beck JP, Schaus JM, Krushinski JH, Chen Q, Beadle CD, Vidal P, Reinhard MR, Dressman BA, Massey SM, Boulet SL, Cohen MP, Watson BM, Tupper D, Gardinier KM, Myers J, Johansson AM, Richardson J, Richards DS, Hembre EJ, Remick DM, Coates DA, Bhardwaj RM, Diseroad BA, Bender D, Stephenson G, Wolfangel CD, Diaz N, Getman BG, Wang XS, Heinz BA, Cramer JW, Zhou X, Maren DL, Falcone JF, Wright RA, Mitchell SN, Carter G, Yang CR, Bruns RF, Svensson KA. Hao J, et al. Among authors: vidal p. J Med Chem. 2019 Oct 10;62(19):8711-8732. doi: 10.1021/acs.jmedchem.9b01234. Epub 2019 Sep 30. J Med Chem. 2019. PMID: 31532644

2

Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.

Bueno AB, Agejas J, Broughton H, Dally R, Durham TB, Espinosa JF, González R, Hahn PJ, Marcos A, Rodríguez R, Sanz G, Soriano JF, Timm D, Vidal P, Yang HC, McCarthy JR. Bueno AB, et al. Among authors: vidal p. J Med Chem. 2017 Dec 14;60(23):9807-9820. doi: 10.1021/acs.jmedchem.7b01304. Epub 2017 Nov 28. J Med Chem. 2017. PMID: 29088532

3

Assignment of absolute configuration on the basis of the conformational effects induced by chiral derivatizing agents: the 2-arylpyrrolidine case.

Vidal P, Pedregal C, Díaz N, Broughton H, Aceña JL, Jiménez A, Espinosa JF. Vidal P, et al. Org Lett. 2007 Oct 11;9(21):4123-6. doi: 10.1021/ol701502e. Epub 2007 Sep 21. Org Lett. 2007. PMID: 17887687

4

A simple method for measuring long-range 1H-13C coupling constants in organic molecules.

Vidal P, Esturau N, Parella T, Espinosa JF. Vidal P, et al. J Org Chem. 2007 Apr 27;72(9):3166-70. doi: 10.1021/jo0621120. Epub 2007 Mar 9. J Org Chem. 2007. PMID: 17346082

5

Conformational behaviour of glycomimetics: NMR and molecular modelling studies of the C-glycoside analogue of the disaccharide methyl beta-D-galactopyranosyl-(1-->3)-beta-D-glucopyranoside.

Vidal P, Vauzeilles B, Blériot Y, Sollogoub M, Sinaÿ P, Jiménez-Barbero J, Espinosa JF. Vidal P, et al. Carbohydr Res. 2007 Sep 3;342(12-13):1910-7. doi: 10.1016/j.carres.2007.04.017. Epub 2007 Apr 29. Carbohydr Res. 2007. PMID: 17517384

6

Solid-phase synthesis of novel trimers containing a phenylstatine core and analysis by high-resolution magic angle spinning.

Taboada L, Prieto L, Vidal P, Espinosa JF, Erickson JA. Taboada L, et al. Among authors: vidal p. J Comb Chem. 2007 Sep-Oct;9(5):748-55. doi: 10.1021/cc070001o. Epub 2007 Jul 14. J Comb Chem. 2007. PMID: 17630807

7

Conformational flexibility around the Gal-β-(1 → 3)-Glc linkage: Experimental evidence for the existence of the anti-ψ conformation in aqueous solution.

Vidal P, Jiménez-Barbero J, Espinosa JF. Vidal P, et al. Carbohydr Res. 2016 Oct 4;433:36-40. doi: 10.1016/j.carres.2016.06.009. Epub 2016 Jul 5. Carbohydr Res. 2016. PMID: 27434833

8

Preorganization of the hydroxyethylene dipeptide isostere: the preferred conformation in solution resembles the conformation bound to BACE.

Vidal P, Timm D, Broughton H, Chen SH, Martín JA, Rivera-Sagredo A, McCarthy JR, Shapiro MJ, Espinosa JF. Vidal P, et al. J Med Chem. 2005 Dec 1;48(24):7623-7. doi: 10.1021/jm050631+. J Med Chem. 2005. PMID: 16302802

9

Measurement of long-range proton-carbon coupling constants from pure in-phase 1D multiplets.

Espinosa JF, Vidal P, Parella T, Gil S. Espinosa JF, et al. Among authors: vidal p. Magn Reson Chem. 2011 Aug;49(8):502-7. doi: 10.1002/mrc.2782. Epub 2011 Jul 12. Magn Reson Chem. 2011. PMID: 21751246

10

Conformational selection in glycomimetics: human galectin-1 only recognizes syn-Ψ-type conformations of β-1,3-linked lactose and its C-glycosyl derivative.

Vidal P, Roldós V, Fernández-Alonso Mdel C, Vauzeilles B, Bleriot Y, Cañada FJ, André S, Gabius HJ, Jiménez-Barbero J, Espinosa JF, Martín-Santamaría S. Vidal P, et al. Chemistry. 2013 Oct 18;19(43):14581-90. doi: 10.1002/chem.201301244. Epub 2013 Sep 17. Chemistry. 2013. PMID: 24105715

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