Barnes N - Search Results

1

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma.

Bryant J, Batis N, Franke AC, Clancey G, Hartley M, Ryan G, Brooks J, Southam AD, Barnes N, Parish J, Roberts S, Khanim F, Spruce R, Mehanna H. Bryant J, et al. Among authors: barnes n. Oncotarget. 2019 Aug 27;10(50):5229-5244. doi: 10.18632/oncotarget.27156. eCollection 2019 Aug 27. Oncotarget. 2019. PMID: 31497252 Free PMC article.

2

5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.

Newman AS, Batis N, Grafton G, Caputo F, Brady CA, Lambert JJ, Peters JA, Gordon J, Brain KL, Powell AD, Barnes NM. Newman AS, et al. Among authors: barnes nm. Br J Pharmacol. 2013 Jul;169(6):1228-38. doi: 10.1111/bph.12213. Br J Pharmacol. 2013. PMID: 23594147 Free PMC article.

3

Serotonin Syndrome: Pathophysiology, Clinical Features, Management, and Potential Future Directions.

Scotton WJ, Hill LJ, Williams AC, Barnes NM. Scotton WJ, et al. Int J Tryptophan Res. 2019 Sep 9;12:1178646919873925. doi: 10.1177/1178646919873925. eCollection 2019. Int J Tryptophan Res. 2019. PMID: 31523132 Free PMC article. Review.

4

Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated-neurotransmission in vitro and in vivo.

Andreetta F, Carboni L, Grafton G, Jeggo R, Whyment AD, van den Top M, Hoyer D, Spanswick D, Barnes NM. Andreetta F, et al. Br J Pharmacol. 2016 May;173(9):1438-51. doi: 10.1111/bph.13432. Epub 2016 Mar 21. Br J Pharmacol. 2016. PMID: 26773257 Free PMC article.

5

Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT₃ A receptor.

Powell AD, Grafton G, Roberts A, Larkin S, O'Neill N, Palandri J, Otvos R, Cooper AJ, Ulens C, Barnes NM. Powell AD, et al. Among authors: barnes nm. Br J Pharmacol. 2016 Dec;173(24):3467-3479. doi: 10.1111/bph.13638. Epub 2016 Nov 1. Br J Pharmacol. 2016. PMID: 27677804 Free PMC article.

6

Overexpression of Orphan Receptor GPR61 Increases cAMP Levels upon Forskolin Stimulation in HEK293 Cells: in vitro and in silico Validation of 5-(Nonyloxy)Tryptamine as a Low-Affinity Inverse Agonist.

Kozielewicz P, Grafton G, Sajkowska-Kozielewicz JJ, Barnes NM. Kozielewicz P, et al. Pharmacology. 2019;104(5-6):377-382. doi: 10.1159/000501926. Epub 2019 Jul 26. Pharmacology. 2019. PMID: 31352450

7

CSTI-300 (SMP-100); a Novel 5-HT₃ Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome.

Roberts A, Grafton G, Powell AD, Brock K, Chen C, Xie D, Huang J, Liu S, Cooper AJ, Brady CA, Qureshi O, Stamataki Z, Manning DD, Moore NA, Sargent BJ, Guzzo PR, Barnes NM. Roberts A, et al. J Pharmacol Exp Ther. 2020 Apr;373(1):122-134. doi: 10.1124/jpet.119.261008. Epub 2020 Feb 26. J Pharmacol Exp Ther. 2020. PMID: 32102919

8

The discovery of diazepinone-based 5-HT3 receptor partial agonists.

Manning DD, Guo C, Zhang Z, Ryan KN, Naginskaya J, Choo SH, Masih L, Earley WG, Wierschke JD, Newman AS, Brady CA, Barnes NM, Guzzo PR. Manning DD, et al. Among authors: barnes nm. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2578-81. doi: 10.1016/j.bmcl.2014.03.074. Epub 2014 Apr 2. Bioorg Med Chem Lett. 2014. PMID: 24755431

9

Identification of 5-HT3A and 5-HT3B receptor subunits in human hippocampus.

Brady CA, Dover TJ, Massoura AN, Princivalle AP, Hope AG, Barnes NM. Brady CA, et al. Among authors: barnes nm. Neuropharmacology. 2007 Apr;52(5):1284-90. doi: 10.1016/j.neuropharm.2007.01.009. Epub 2007 Jan 21. Neuropharmacology. 2007. PMID: 17327132

10

The 5-HT3 receptor--the relationship between structure and function.

Barnes NM, Hales TG, Lummis SC, Peters JA. Barnes NM, et al. Neuropharmacology. 2009 Jan;56(1):273-84. doi: 10.1016/j.neuropharm.2008.08.003. Epub 2008 Aug 12. Neuropharmacology. 2009. PMID: 18761359 Free PMC article. Review.

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