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An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE. Futch HS, et al. Among authors: cruz pe. J Exp Med. 2019 Nov 4;216(11):2479-2491. doi: 10.1084/jem.20190430. Epub 2019 Aug 29. J Exp Med. 2019. PMID: 31467037 Free PMC article.
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.
Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, Moore BD, Liu X, Ceballos-Diaz C, Rosario AM, Medway C, Janus C, Li HD, Dickson DW, Giasson BI, Price ND, Younkin SG, Ertekin-Taner N, Golde TE. Chakrabarty P, et al. Among authors: cruz pe. J Exp Med. 2018 Sep 3;215(9):2247-2264. doi: 10.1084/jem.20180484. J Exp Med. 2018. PMID: 30158114 Free PMC article.
Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.
Levites Y, Funk C, Wang X, Chakrabarty P, McFarland KN, Bramblett B, O'Neal V, Liu X, Ladd T, Robinson M, Allen M, Carrasquillo MM, Dickson D, Cruz P, Ryu D, Li HD, Price ND, Ertekin-Taner N, Golde TE. Levites Y, et al. Mol Neurodegener. 2021 May 6;16(1):32. doi: 10.1186/s13024-021-00453-4. Mol Neurodegener. 2021. PMID: 33957936 Free PMC article.
IFN-γ promotes τ phosphorylation without affecting mature tangles.
Li A, Ceballos-Diaz C, DiNunno N, Levites Y, Cruz PE, Lewis J, Golde TE, Chakrabarty P. Li A, et al. Among authors: cruz pe. FASEB J. 2015 Oct;29(10):4384-98. doi: 10.1096/fj.15-275834. Epub 2015 Jul 8. FASEB J. 2015. PMID: 26156074 Free PMC article.
Short Aβ peptides attenuate Aβ42 toxicity in vivo.
Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, Rincon-Limas D, Fernandez-Funez P, Golde TE. Moore BD, et al. Among authors: cruz pe. J Exp Med. 2018 Jan 2;215(1):283-301. doi: 10.1084/jem.20170600. Epub 2017 Dec 5. J Exp Med. 2018. PMID: 29208777 Free PMC article.
Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.
Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y. Ayers JI, et al. Among authors: cruz pe. Mol Ther. 2015 Jan;23(1):53-62. doi: 10.1038/mt.2014.180. Epub 2014 Sep 17. Mol Ther. 2015. PMID: 25228069 Free PMC article.
138 results