Yachnin BJ - Search Results

1

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.

Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN. Toulouse JL, et al. Among authors: yachnin bj. ACS Omega. 2019 Jun 10;4(6):10056-10069. doi: 10.1021/acsomega.9b00640. eCollection 2019 Jun 30. ACS Omega. 2019. PMID: 31460098 Free PMC article.

2

Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance.

Volpato JP, Yachnin BJ, Blanchet J, Guerrero V, Poulin L, Fossati E, Berghuis AM, Pelletier JN. Volpato JP, et al. Among authors: yachnin bj. J Biol Chem. 2009 Jul 24;284(30):20079-89. doi: 10.1074/jbc.M109.018010. Epub 2009 May 28. J Biol Chem. 2009. PMID: 19478082 Free PMC article.

3

Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure.

Yachnin BJ, Colin DY, Volpato JP, Ebert M, Pelletier JN, Berghuis AM. Yachnin BJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1316-22. doi: 10.1107/S1744309111030417. Epub 2011 Oct 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 22102224 Free PMC article.

4

The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure.

Yachnin BJ, Lau PCK, Berghuis AM. Yachnin BJ, et al. Biochim Biophys Acta. 2016 Dec;1864(12):1641-1648. doi: 10.1016/j.bbapap.2016.08.015. Epub 2016 Aug 26. Biochim Biophys Acta. 2016. PMID: 27570148

5

Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis.

Yachnin BJ, McEvoy MB, MacCuish RJ, Morley KL, Lau PC, Berghuis AM. Yachnin BJ, et al. ACS Chem Biol. 2014 Dec 19;9(12):2843-51. doi: 10.1021/cb500442e. Epub 2014 Oct 21. ACS Chem Biol. 2014. PMID: 25265531

6

Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme.

Baettig OM, Shi K, Yachnin BJ, Burk DL, Berghuis AM. Baettig OM, et al. Among authors: yachnin bj. FEBS J. 2016 Aug;283(16):3029-38. doi: 10.1111/febs.13788. Epub 2016 Jul 7. FEBS J. 2016. PMID: 27333541 Free PMC article.

7

The substrate-bound crystal structure of a Baeyer-Villiger monooxygenase exhibits a Criegee-like conformation.

Yachnin BJ, Sprules T, McEvoy MB, Lau PC, Berghuis AM. Yachnin BJ, et al. J Am Chem Soc. 2012 May 9;134(18):7788-95. doi: 10.1021/ja211876p. Epub 2012 Apr 27. J Am Chem Soc. 2012. PMID: 22506764 Free PMC article.

8

Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor.

Mirza IA, Yachnin BJ, Wang S, Grosse S, Bergeron H, Imura A, Iwaki H, Hasegawa Y, Lau PC, Berghuis AM. Mirza IA, et al. Among authors: yachnin bj. J Am Chem Soc. 2009 Jul 1;131(25):8848-54. doi: 10.1021/ja9010578. J Am Chem Soc. 2009. PMID: 19385644

9

Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme.

Yachnin BJ, Khare SD. Yachnin BJ, et al. Protein Eng Des Sel. 2017 Apr 1;30(4):321-331. doi: 10.1093/protein/gzx005. Protein Eng Des Sel. 2017. PMID: 28160000 Free PMC article.

10

Computational Design of a Photocontrolled Cytosine Deaminase.

Blacklock KM, Yachnin BJ, Woolley GA, Khare SD. Blacklock KM, et al. Among authors: yachnin bj. J Am Chem Soc. 2018 Jan 10;140(1):14-17. doi: 10.1021/jacs.7b08709. Epub 2017 Dec 28. J Am Chem Soc. 2018. PMID: 29251923 Free PMC article.

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