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Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
ACS Omega. 2019 Jun 10;4(6):10056-10069. doi: 10.1021/acsomega.9b00640. eCollection 2019 Jun 30.
ACS Omega. 2019.
PMID: 31460098
Free PMC article.
Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.
Toulouse JL, Shi G, Lemay-St-Denis C, Ebert MCCJC, Deon D, Gagnon M, Ruediger E, Saint-Jacques K, Forge D, Vanden Eynde JJ, Marinier A, Ji X, Pelletier JN.
Toulouse JL, et al. Among authors: saint jacques k.
ACS Med Chem Lett. 2020 Sep 28;11(11):2261-2267. doi: 10.1021/acsmedchemlett.0c00393. eCollection 2020 Nov 12.
ACS Med Chem Lett. 2020.
PMID: 33214838
Free PMC article.
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Access to hexahydroazepinone heterocycles via palladium-catalysed C(sp3)-H alkenylation/ring-opening of cyclopropanes.
Saint-Jacques K, Ladd CL, Charette AB.
Saint-Jacques K, et al.
Chem Commun (Camb). 2022 Jul 5;58(54):7550-7553. doi: 10.1039/d2cc01917e.
Chem Commun (Camb). 2022.
PMID: 35707937
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