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Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands.
Kale SS, Bergeron-Brlek M, Wu Y, Kumar MG, Pham MV, Bortoli J, Vesin J, Kong XD, Machado JF, Deyle K, Gonschorek P, Turcatti G, Cendron L, Angelini A, Heinis C. Kale SS, et al. Among authors: heinis c. Sci Adv. 2019 Aug 21;5(8):eaaw2851. doi: 10.1126/sciadv.aaw2851. eCollection 2019 Aug. Sci Adv. 2019. PMID: 31457083 Free PMC article.
Enzymatic cyclisation of peptides with a transglutaminase.
Touati J, Angelini A, Hinner MJ, Heinis C. Touati J, et al. Among authors: heinis c. Chembiochem. 2011 Jan 3;12(1):38-42. doi: 10.1002/cbic.201000451. Chembiochem. 2011. PMID: 21154802 No abstract available.
Chemical macrocyclization of peptides fused to antibody Fc fragments.
Angelini A, Diderich P, Morales-Sanfrutos J, Thurnheer S, Hacker D, Menin L, Heinis C. Angelini A, et al. Among authors: heinis c. Bioconjug Chem. 2012 Sep 19;23(9):1856-63. doi: 10.1021/bc300184m. Epub 2012 Aug 10. Bioconjug Chem. 2012. PMID: 22812498
Peptide ligands stabilized by small molecules.
Chen S, Bertoldo D, Angelini A, Pojer F, Heinis C. Chen S, et al. Among authors: heinis c. Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1602-6. doi: 10.1002/anie.201309459. Epub 2014 Jan 22. Angew Chem Int Ed Engl. 2014. PMID: 24453110
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