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5-Chloro-2-thiophenyl-1,2,3-triazolylmethyldihydroquinolines as dual inhibitors of Mycobacterium tuberculosis and influenza virus: Synthesis and evaluation.
Marvadi SK, Krishna VS, Sinegubova EO, Volobueva AS, Esaulkova YL, Muryleva AA, Tentler DG, Sriram D, Zarubaev VV, Kantevari S. Marvadi SK, et al. Among authors: tentler dg. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2664-2669. doi: 10.1016/j.bmcl.2019.07.040. Epub 2019 Jul 24. Bioorg Med Chem Lett. 2019. PMID: 31375291
Discovery of Novel Isatin-Based p53 Inducers.
Davidovich P, Aksenova V, Petrova V, Tentler D, Orlova D, Smirnov S, Gurzhiy V, Okorokov AL, Garabadzhiu A, Melino G, Barlev N, Tribulovich V. Davidovich P, et al. ACS Med Chem Lett. 2015 Jul 6;6(8):856-60. doi: 10.1021/acsmedchemlett.5b00011. eCollection 2015 Aug 13. ACS Med Chem Lett. 2015. PMID: 26288684 Free PMC article.
Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis.
Fedorova O, Daks A, Petrova V, Petukhov A, Lezina L, Shuvalov O, Davidovich P, Kriger D, Lomert E, Tentler D, Kartsev V, Uyanik B, Tribulovich V, Demidov O, Melino G, Barlev NA. Fedorova O, et al. Cell Cycle. 2018;17(15):1917-1930. doi: 10.1080/15384101.2018.1506664. Epub 2018 Sep 5. Cell Cycle. 2018. PMID: 30109812 Free PMC article.
KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress.
Lezina L, Aksenova V, Ivanova T, Purmessur N, Antonov AV, Tentler D, Fedorova O, Garabadgiu AV, Talianidis I, Melino G, Barlev NA. Lezina L, et al. Cell Death Differ. 2014 Dec;21(12):1889-99. doi: 10.1038/cdd.2014.108. Epub 2014 Aug 15. Cell Death Differ. 2014. PMID: 25124555 Free PMC article.
12 results