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Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling.
Feelisch M, Akaike T, Griffiths K, Ida T, Prysyazhna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M. Feelisch M, et al. Cardiovasc Res. 2020 Jan 1;116(1):51-62. doi: 10.1093/cvr/cvz202. Cardiovasc Res. 2020. PMID: 31372656 Free PMC article.
Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood.
Rassaf T, Kleinbongard P, Preik M, Dejam A, Gharini P, Lauer T, Erckenbrecht J, Duschin A, Schulz R, Heusch G, Feelisch M, Kelm M. Rassaf T, et al. Among authors: feelisch m. Circ Res. 2002 Sep 20;91(6):470-7. doi: 10.1161/01.res.0000035038.41739.cb. Circ Res. 2002. PMID: 12242264 Clinical Trial.
Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms.
Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Lim CC, et al. Among authors: feelisch m. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2144-53. doi: 10.1152/ajpheart.00673.2009. Epub 2009 Oct 2. Am J Physiol Heart Circ Physiol. 2009. PMID: 19801492 Free PMC article.
265 results