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Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling.
Feelisch M, Akaike T, Griffiths K, Ida T, Prysyazhna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M. Feelisch M, et al. Among authors: akaike t. Cardiovasc Res. 2020 Jan 1;116(1):51-62. doi: 10.1093/cvr/cvz202. Cardiovasc Res. 2020. PMID: 31372656 Free PMC article.
Frontiers in nitric oxide and redox signaling.
Akaike T, van der Vliet A, Eaton P. Akaike T, et al. Nitric Oxide. 2011 Aug 1;25(2):57-8. doi: 10.1016/j.niox.2011.05.002. Epub 2011 May 10. Nitric Oxide. 2011. PMID: 21596152 Free article. No abstract available.
Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.
Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S, Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T. Ida T, et al. Among authors: akaike t. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7606-11. doi: 10.1073/pnas.1321232111. Epub 2014 Apr 14. Proc Natl Acad Sci U S A. 2014. PMID: 24733942 Free PMC article.
Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.
Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M. Nakano S, et al. Among authors: akaike t. J Mol Med (Berl). 2015 Aug;93(8):879-89. doi: 10.1007/s00109-015-1271-5. Epub 2015 Mar 6. J Mol Med (Berl). 2015. PMID: 25740079
712 results