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Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.
Olin-Sandoval V, Yu JSL, Miller-Fleming L, Alam MT, Kamrad S, Correia-Melo C, Haas R, Segal J, Peña Navarro DA, Herrera-Dominguez L, Méndez-Lucio O, Vowinckel J, Mülleder M, Ralser M. Olin-Sandoval V, et al. Among authors: yu jsl. Nature. 2019 Aug;572(7768):249-253. doi: 10.1038/s41586-019-1442-6. Epub 2019 Jul 31. Nature. 2019. PMID: 31367038 Free PMC article.
AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.
Dunn S, Eberlein C, Yu J, Gris-Oliver A, Ong SH, Yelland U, Cureton N, Staniszewska A, McEwen R, Fox M, Pilling J, Hopcroft P, Coker EA, Jaaks P, Garnett MJ, Isherwood B, Serra V, Davies BR, Barry ST, Lynch JT, Yusa K. Dunn S, et al. Oncogene. 2022 Nov;41(46):5046-5060. doi: 10.1038/s41388-022-02482-9. Epub 2022 Oct 14. Oncogene. 2022. PMID: 36241868 Free PMC article.
Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan.
Correia-Melo C, Kamrad S, Tengölics R, Messner CB, Trebulle P, Townsend S, Jayasree Varma S, Freiwald A, Heineike BM, Campbell K, Herrera-Dominguez L, Kaur Aulakh S, Szyrwiel L, Yu JSL, Zelezniak A, Demichev V, Mülleder M, Papp B, Alam MT, Ralser M. Correia-Melo C, et al. Among authors: yu jsl. Cell. 2023 Jan 5;186(1):63-79.e21. doi: 10.1016/j.cell.2022.12.007. Cell. 2023. PMID: 36608659 Free article.
Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.
Yu JSL, Correia-Melo C, Zorrilla F, Herrera-Dominguez L, Wu MY, Hartl J, Campbell K, Blasche S, Kreidl M, Egger AS, Messner CB, Demichev V, Freiwald A, Mülleder M, Howell M, Berman J, Patil KR, Alam MT, Ralser M. Yu JSL, et al. Nat Microbiol. 2022 Apr;7(4):542-555. doi: 10.1038/s41564-022-01072-5. Epub 2022 Mar 21. Nat Microbiol. 2022. PMID: 35314781 Free PMC article.
The metabolic growth limitations of petite cells lacking the mitochondrial genome.
Vowinckel J, Hartl J, Marx H, Kerick M, Runggatscher K, Keller MA, Mülleder M, Day J, Weber M, Rinnerthaler M, Yu JSL, Aulakh SK, Lehmann A, Mattanovich D, Timmermann B, Zhang N, Dunn CD, MacRae JI, Breitenbach M, Ralser M. Vowinckel J, et al. Among authors: yu jsl. Nat Metab. 2021 Nov;3(11):1521-1535. doi: 10.1038/s42255-021-00477-6. Epub 2021 Nov 18. Nat Metab. 2021. PMID: 34799698 Free PMC article.
Ultra-fast proteomics with Scanning SWATH.
Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jürgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mülleder M, Tate S, Ralser M. Messner CB, et al. Among authors: yu jsl. Nat Biotechnol. 2021 Jul;39(7):846-854. doi: 10.1038/s41587-021-00860-4. Epub 2021 Mar 25. Nat Biotechnol. 2021. PMID: 33767396 Free PMC article.
15 results