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A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Pérez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaró A, Bartolini M, De Simone A, Andrisano V, Pérez B, Sabate R, Sureda FX, Vázquez S, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: vazquez s. Eur J Med Chem. 2019 Oct 15;180:613-626. doi: 10.1016/j.ejmech.2019.07.051. Epub 2019 Jul 17. Eur J Med Chem. 2019. PMID: 31351393 Free article.
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.
Camps P, Duque MD, Vázquez S, Naesens L, De Clercq E, Sureda FX, López-Querol M, Camins A, Pallàs M, Prathalingam SR, Kelly JM, Romero V, Ivorra D, Cortés D. Camps P, et al. Among authors: vazquez s. Bioorg Med Chem. 2008 Dec 1;16(23):9925-36. doi: 10.1016/j.bmc.2008.10.028. Epub 2008 Oct 17. Bioorg Med Chem. 2008. PMID: 18954995 Free PMC article.
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
Duque MD, Camps P, Profire L, Montaner S, Vázquez S, Sureda FX, Mallol J, López-Querol M, Naesens L, De Clercq E, Prathalingam SR, Kelly JM. Duque MD, et al. Among authors: vazquez s. Bioorg Med Chem. 2009 Apr 15;17(8):3198-206. doi: 10.1016/j.bmc.2009.02.007. Epub 2009 Feb 13. Bioorg Med Chem. 2009. PMID: 19251424 Free PMC article.
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
Rey-Carrizo M, Torres E, Ma C, Barniol-Xicota M, Wang J, Wu Y, Naesens L, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Rey-Carrizo M, et al. Among authors: vazquez s. J Med Chem. 2013 Nov 27;56(22):9265-74. doi: 10.1021/jm401340p. Epub 2013 Nov 15. J Med Chem. 2013. PMID: 24237039 Free PMC article.
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.
Rey-Carrizo M, Barniol-Xicota M, Ma C, Frigolé-Vivas M, Torres E, Naesens L, Llabrés S, Juárez-Jiménez J, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Rey-Carrizo M, et al. Among authors: vazquez s. J Med Chem. 2014 Jul 10;57(13):5738-47. doi: 10.1021/jm5005804. Epub 2014 Jun 30. J Med Chem. 2014. PMID: 24941437 Free PMC article.
737 results