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Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Soliai MM, Kato A, Helling BA, Stanhope CT, Norton JE, Naughton KA, Klinger AI, Thompson EE, Clay SM, Kim S, Celedón JC, Gern JE, Jackson DJ, Altman MC, Kern RC, Tan BK, Schleimer RP, Nicolae DL, Pinto JM, Ober C. Soliai MM, et al. Among authors: clay sm. Genome Med. 2021 Oct 10;13(1):157. doi: 10.1186/s13073-021-00967-y. Genome Med. 2021. PMID: 34629083 Free PMC article.
Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region.
Aneas I, Decker DC, Howard CL, Sobreira DR, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Tena J, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Gomez-Skarmeta JL, Schoetler N, Ober C, Sperling AI, Nóbrega MA. Aneas I, et al. Among authors: clay sm. Nat Commun. 2021 Oct 21;12(1):6115. doi: 10.1038/s41467-021-26347-z. Nat Commun. 2021. PMID: 34675193 Free PMC article.
DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
Magnaye KM, Clay SM, Nicodemus-Johnson J, Naughton KA, Huffman J, Altman MC, Jackson DJ, Gern JE, Hogarth DK, Naureckas ET, White SR, Ober C. Magnaye KM, et al. Among authors: clay sm. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2116467119. doi: 10.1073/pnas.2116467119. Epub 2022 Jun 6. Proc Natl Acad Sci U S A. 2022. PMID: 35666868 Free PMC article.
Current insights into the genetics of food allergy.
Kanchan K, Clay S, Irizar H, Bunyavanich S, Mathias RA. Kanchan K, et al. J Allergy Clin Immunol. 2021 Jan;147(1):15-28. doi: 10.1016/j.jaci.2020.10.039. Epub 2021 Jan 5. J Allergy Clin Immunol. 2021. PMID: 33436162 Free PMC article. Review.
13 results