Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.
González AE, Muñoz VC, Cavieres VA, Bustamante HA, Cornejo VH, Januário YC, González I, Hetz C, daSilva LL, Rojas-Fernández A, Hay RT, Mardones GA, Burgos PV.
González AE, et al.
FASEB J. 2017 Jun;31(6):2446-2459. doi: 10.1096/fj.201600713R. Epub 2017 Mar 2.
FASEB J. 2017.
PMID: 28254759
Altogether, our results indicate that autophagosomes are key organelles to help avoid C99 accumulation preventing its deleterious effects.-Gonzalez, A. E., Munoz, V. C., Cavieres, V. A., Bustamante, H. A., Cornejo, V.-H., Januario, Y. C., Gonzalez, I., Hetz, …
Altogether, our results indicate that autophagosomes are key organelles to help avoid C99 accumulation preventing its deleterious effects.-G …