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Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv. 2019 Jun 19;5(6):eaax2650. doi: 10.1126/sciadv.aax2650. eCollection 2019 Jun.
Sci Adv. 2019.
PMID: 31223657
Free PMC article.
Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.
Thomas-Tran R, Du Bois J.
Thomas-Tran R, et al.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5856-61. doi: 10.1073/pnas.1603486113. Epub 2016 May 9.
Proc Natl Acad Sci U S A. 2016.
PMID: 27162340
Free PMC article.
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Asymmetric synthesis of batrachotoxin: Enantiomeric toxins show functional divergence against NaV.
Logan MM, Toma T, Thomas-Tran R, Du Bois J.
Logan MM, et al. Among authors: thomas tran r.
Science. 2016 Nov 18;354(6314):865-869. doi: 10.1126/science.aag2981.
Science. 2016.
PMID: 27856903
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Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid.
Walker JR, Merit JE, Thomas-Tran R, Tang DTY, Du Bois J.
Walker JR, et al. Among authors: thomas tran r.
Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1689-1693. doi: 10.1002/anie.201811717. Epub 2019 Jan 2.
Angew Chem Int Ed Engl. 2019.
PMID: 30488599
Free PMC article.
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A selective class of inhibitors for the CLC-Ka chloride ion channel.
Koster AK, Wood CAP, Thomas-Tran R, Chavan TS, Almqvist J, Choi KH, Du Bois J, Maduke M.
Koster AK, et al. Among authors: thomas tran r.
Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4900-E4909. doi: 10.1073/pnas.1720584115. Epub 2018 Apr 18.
Proc Natl Acad Sci U S A. 2018.
PMID: 29669921
Free PMC article.
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Discovery of Potent and Selective PI3Kγ Inhibitors.
Drew SL, Thomas-Tran R, Beatty JW, Fournier J, Lawson KV, Miles DH, Mata G, Sharif EU, Yan X, Mailyan AK, Ginn E, Chen J, Wong K, Soni D, Dhanota P, Chen PY, Shaqfeh SG, Meleza C, Pham AT, Chen A, Zhao X, Banuelos J, Jin L, Schindler U, Walters MJ, Young SW, Walker NP, Leleti MR, Powers JP, Jeffrey JL.
Drew SL, et al. Among authors: thomas tran r.
J Med Chem. 2020 Oct 8;63(19):11235-11257. doi: 10.1021/acs.jmedchem.0c01203. Epub 2020 Sep 16.
J Med Chem. 2020.
PMID: 32865410
Free article.
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Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73.
Beatty JW, Lindsey EA, Thomas-Tran R, Debien L, Mandal D, Jeffrey JL, Tran AT, Fournier J, Jacob SD, Yan X, Drew SL, Ginn E, Chen A, Pham AT, Zhao S, Jin L, Young SW, Walker NP, Leleti MR, Moschütz S, Sträter N, Powers JP, Lawson KV.
Beatty JW, et al. Among authors: thomas tran r.
J Med Chem. 2020 Apr 23;63(8):3935-3955. doi: 10.1021/acs.jmedchem.9b01713. Epub 2020 Apr 8.
J Med Chem. 2020.
PMID: 32212732
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Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors.
Miles DH, Yan X, Thomas-Tran R, Fournier J, Sharif EU, Drew SL, Mata G, Lawson KV, Ginn E, Wong K, Soni D, Dhanota P, Shaqfeh SG, Meleza C, Chen A, Pham AT, Park T, Swinarski D, Banuelos J, Schindler U, Walters MJ, Walker NP, Zhao X, Young SW, Chen J, Jin L, Leleti MR, Powers JP, Jeffrey JL.
Miles DH, et al. Among authors: thomas tran r.
ACS Med Chem Lett. 2020 Sep 24;11(11):2244-2252. doi: 10.1021/acsmedchemlett.0c00387. eCollection 2020 Nov 12.
ACS Med Chem Lett. 2020.
PMID: 33214836
Free PMC article.
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