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Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver.
Toxicol Lett. 2019 Oct 1;313:1-10. doi: 10.1016/j.toxlet.2019.05.024. Epub 2019 Jun 4.
Toxicol Lett. 2019.
PMID: 31170421
Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.
Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P.
Carazo A, et al. Among authors: horvatova a.
Toxicol Lett. 2017 Jan 4;265:86-96. doi: 10.1016/j.toxlet.2016.11.013. Epub 2016 Nov 18.
Toxicol Lett. 2017.
PMID: 27871908
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The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids.
Smutny T, Dusek J, Hyrsova L, Nekvindova J, Horvatova A, Micuda S, Gerbal-Chaloin S, Pavek P.
Smutny T, et al. Among authors: horvatova a.
Acta Pharm Sin B. 2020 Jan;10(1):136-152. doi: 10.1016/j.apsb.2019.09.010. Epub 2019 Oct 21.
Acta Pharm Sin B. 2020.
PMID: 31998607
Free PMC article.
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Ursodeoxycholyl lysophosphatidylethanolamide negatively regulates TLR-mediated lipopolysaccharide response in human THP-1-derived macrophages.
Horvatova A, Utaipan T, Otto AC, Zhang Y, Gan-Schreier H, Pavek P, Pathil A, Stremmel W, Chamulitrat W.
Horvatova A, et al.
Eur J Pharmacol. 2018 Apr 15;825:63-74. doi: 10.1016/j.ejphar.2018.02.030. Epub 2018 Feb 20.
Eur J Pharmacol. 2018.
PMID: 29475064
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