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Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Thiadiazole Derivatives as Potent P2X7 Receptor Inhibitors.
Gonzaga DTG, Oliveira FH, von Ranke NL, Pinho GQ, Salles JP, Bello ML, Rodrigues CR, Castro HC, de Souza HVCM, Reis CRC, Leme RPP, Mafra JCM, Pinheiro LCS, Hoelz LVB, Boechat N, Faria RX. Gonzaga DTG, et al. Among authors: faria rx. Front Chem. 2019 Apr 30;7:261. doi: 10.3389/fchem.2019.00261. eCollection 2019. Front Chem. 2019. PMID: 31134177 Free PMC article.
1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo.
Gonzaga DTG, Ferreira LBG, Moreira Maramaldo Costa TE, von Ranke NL, Anastácio Furtado Pacheco P, Sposito Simões AP, Arruda JC, Dantas LP, de Freitas HR, de Melo Reis RA, Penido C, Bello ML, Castro HC, Rodrigues CR, Ferreira VF, Faria RX, da Silva FC. Gonzaga DTG, et al. Among authors: faria rx. Eur J Med Chem. 2017 Oct 20;139:698-717. doi: 10.1016/j.ejmech.2017.08.034. Epub 2017 Aug 16. Eur J Med Chem. 2017. PMID: 28858765
1,4-Naphthoquinones potently inhibiting P2X7 receptor activity.
Faria RX, Oliveira FH, Salles JP, Oliveira AS, von Ranke NL, Bello ML, Rodrigues CR, Castro HC, Louvis AR, Martins DL, Ferreira VF. Faria RX, et al. Eur J Med Chem. 2018 Jan 1;143:1361-1372. doi: 10.1016/j.ejmech.2017.10.033. Epub 2017 Oct 23. Eur J Med Chem. 2018. PMID: 29133043
8-Hydroxy-2-(1H-1,2,3-triazol-1-yl)-1,4-naphtoquinone derivatives inhibited P2X7 Receptor-Induced dye uptake into murine Macrophages.
Pacheco PAF, Galvão RMS, Faria AFM, Von Ranke NL, Rangel MS, Ribeiro TM, Bello ML, Rodrigues CR, Ferreira VF, da Rocha DR, Faria RX. Pacheco PAF, et al. Among authors: faria rx, faria afm. Bioorg Med Chem. 2019 Apr 15;27(8):1449-1455. doi: 10.1016/j.bmc.2018.11.036. Epub 2018 Nov 27. Bioorg Med Chem. 2019. PMID: 30528164
Synthesis of new N,S-acetal analogs derived from juglone with cytotoxic activity against Trypanossoma cruzi.
Pacheco PAF, de Menezes Ribeiro T, Dos Santos Galvão RM, Dos Santos EG, Faria AFM, von Ranke NL, Bello ML, Rodrigues CR, Ferreira VF, Souza ALA, de Jesús Hardoim D, da Silva Calabrese K, Faria RX, da Rocha DR. Pacheco PAF, et al. Among authors: faria rx, faria afm. J Bioenerg Biomembr. 2020 Jun;52(3):199-213. doi: 10.1007/s10863-020-09834-8. Epub 2020 May 17. J Bioenerg Biomembr. 2020. PMID: 32418003
P2X7 receptor inhibition by 2-amino-3-aryl-1,4-naphthoquinones.
de Luna Martins D, Borges AA, E Silva NADA, Faria JV, Hoelz LVB, de Souza HVCM, Bello ML, Boechat N, Ferreira VF, Faria RX. de Luna Martins D, et al. Among authors: faria rx, faria jv. Bioorg Chem. 2020 Nov;104:104278. doi: 10.1016/j.bioorg.2020.104278. Epub 2020 Sep 17. Bioorg Chem. 2020. PMID: 33010623
69 results