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Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking.
Schmidtke C, Tiede S, Thelen M, Käkelä R, Jabs S, Makrypidi G, Sylvester M, Schweizer M, Braren I, Brocke-Ahmadinejad N, Cotman SL, Schulz A, Gieselmann V, Braulke T. Schmidtke C, et al. Among authors: kakela r. J Biol Chem. 2019 Jun 14;294(24):9592-9604. doi: 10.1074/jbc.RA119.008852. Epub 2019 Apr 30. J Biol Chem. 2019. PMID: 31040178 Free PMC article.
Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.
Kollmann K, Damme M, Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski JC, Käkelä R, Walkley SU, Braulke T. Kollmann K, et al. Among authors: kakela r. Brain. 2012 Sep;135(Pt 9):2661-75. doi: 10.1093/brain/aws209. Brain. 2012. PMID: 22961545 Free PMC article.
Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.
Le Joncour V, Filppu P, Hyvönen M, Holopainen M, Turunen SP, Sihto H, Burghardt I, Joensuu H, Tynninen O, Jääskeläinen J, Weller M, Lehti K, Käkelä R, Laakkonen P. Le Joncour V, et al. Among authors: kakela r. EMBO Mol Med. 2019 Jun;11(6):e9034. doi: 10.15252/emmm.201809034. EMBO Mol Med. 2019. PMID: 31068339 Free PMC article.
108 results