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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Zak M, Hanan EJ, Lupardus P, Brown DG, Robinson C, Siu M, Lyssikatos JP, Romero FA, Zhao G, Kellar T, Mendonca R, Ray NC, Goodacre SC, Crackett PH, McLean N, Hurley CA, Yuen PW, Cheng YX, Liu X, Liimatta M, Kohli PB, Nonomiya J, Salmon G, Buckley G, Lloyd J, Gibbons P, Ghilardi N, Kenny JR, Johnson A. Zak M, et al. Among authors: robinson c. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1522-1531. doi: 10.1016/j.bmcl.2019.04.008. Epub 2019 Apr 4. Bioorg Med Chem Lett. 2019. PMID: 30981576
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
Skerratt SE, Andrews M, Bagal SK, Bilsland J, Brown D, Bungay PJ, Cole S, Gibson KR, Jones R, Morao I, Nedderman A, Omoto K, Robinson C, Ryckmans T, Skinner K, Stupple P, Waldron G. Skerratt SE, et al. Among authors: robinson c. J Med Chem. 2016 Nov 23;59(22):10084-10099. doi: 10.1021/acs.jmedchem.6b00850. Epub 2016 Nov 4. J Med Chem. 2016. PMID: 27766865
A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode.
Pande V, Sun W, Beke L, Berthelot D, Brehmer D, Brown D, Corbera J, Irving S, Meerpoel L, Nys T, Parade M, Robinson C, Sommen C, Viellevoye M, Wu T, Thuring JW. Pande V, et al. Among authors: robinson c. ACS Med Chem Lett. 2020 Sep 28;11(11):2227-2231. doi: 10.1021/acsmedchemlett.0c00355. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214833 Free PMC article.
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Han S, Czerwinski RM, Caspers NL, Limburg DC, Ding W, Wang H, Ohren JF, Rajamohan F, McLellan TJ, Unwalla R, Choi C, Parikh MD, Seth N, Edmonds J, Phillips C, Shakya S, Li X, Spaulding V, Hughes S, Cook A, Robinson C, Mathias JP, Navratilova I, Medley QG, Anderson DR, Kurumbail RG, Aulabaugh A. Han S, et al. Among authors: robinson c. Biochem J. 2014 Jun 1;460(2):211-22. doi: 10.1042/BJ20131139. Biochem J. 2014. PMID: 24593284
Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier.
Senoo N, Chinthapalli DK, Baile MG, Golla VK, Saha B, Oluwole AO, Ogunbona OB, Saba JA, Munteanu T, Valdez Y, Whited K, Sheridan MS, Chorev D, Alder NN, May ER, Robinson CV, Claypool SM. Senoo N, et al. Among authors: robinson cv. EMBO J. 2024 Jun 5. doi: 10.1038/s44318-024-00132-2. Online ahead of print. EMBO J. 2024. PMID: 38839991 Free article.
Human activities shape global patterns of decomposition rates in rivers.
Tiegs SD, Capps KA, Costello DM, Schmidt JP, Patrick CJ, Follstad Shah JJ, LeRoy CJ; CELLDEX Consortium‡; Acuña V, Albariño R, Allen DC, Alonso C, Andino P, Arango C, Aroviita J, Barbosa MVM, Barmuta LA, Baxter C, Bellinger B, Boyero L, Bragina L, Brown LE, Bruder A, Bruesewitz DA, Burdon F, Callisto M, Camacho A, Canhoto C, Castillo MM, Chauvet E, Clapcott J, Colas F, Colón-Gaud C, Cornut J, Crespo-Pérez V, Cross WF, Culp J, Danger M, Dangles O, de Eyto E, Derry AM, Villanueva VD, Douglas MM, Elosegi A, Encalada AC, Entrekin S, Espinosa R, Ferreira V, Ferriol C, Flanagan KM, Flecker AS, Fleituch T, Frainer A, Friberg N, Frost PC, Garcia EA, García-Lago L, Soto PEG, Gessner MO, Ghate S, Giling DP, Gilmer A, Gonçalves JF Jr, Gonzales RK, Graça MAS, Grace M, Griffiths NA, Grossart HP, Guérold F, Gulis V, Gutiérrez-Fonseca PE, Hepp LU, Higgins S, Hishi T, Huddart J, Hudson J, Imberger M, Iñiguez-Armijos C, Isken MW, Iwata T, Janetski DJ, Kirkwood AE, Koning AA, Kosten S, Kuehn KA, Laudon H, Leavitt PR, Lemes da Silva AL, Leroux S, Lisi PJ, MacKenzie R, Marcarelli AM, Masese FO, McIntyre PB, McKie BG, Medeiros A, Meissner K, Miliša M, Mishra S, Miyake Y, Moerke A, Mombrikotb S, Mooney… See abstract for full author list ➔ Tiegs SD, et al. Among authors: robinson ct. Science. 2024 May 30:eadn1262. doi: 10.1126/science.adn1262. Online ahead of print. Science. 2024. PMID: 38815088
Pulmonary embolism versus pulmonary vasculitis in Hughes-Stovin syndrome: Characteristic computed tomography pulmonary angiographic findings and diagnostic and therapeutic implications. HSS International Study Group.
Emad Y, Ragab Y, Farber HW, Erkan D, Ibrahim O, Kindermann M, Tekavec-Trkanjec J, Jayakrishnan B, El-Shaarawy N, Kechida M, Young P, Pankl S, Fabi M, Bawaskar P, Kably I, Ghirardo S, Frikha F, Abou-Zeid A, Hassan M, Robinson C, Abdelbary MH, Tornes L, Margolesky J, Barman B, Bennji S, Agarwala MK, Alhusseiny K, Amezyane T, Silva RS, Cruz V, Niemeyer B, Al-Zeedy K, Al-Jahdali H, Jaramillo N, Demirkan S, Guffroy A, Kim JT, Ruffer N, Tharwat S, Cozzi D, Abdelali M, Joy TC, Sayed M, Sherwina J, Gheita T, Rasker JJ. Emad Y, et al. Among authors: robinson c. Thromb Res. 2024 Jul;239:109040. doi: 10.1016/j.thromres.2024.109040. Epub 2024 May 22. Thromb Res. 2024. PMID: 38795561 Free article.
4,345 results