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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg Med Chem Lett. 2019 Jun 15;29(12):1522-1531. doi: 10.1016/j.bmcl.2019.04.008. Epub 2019 Apr 4.
Bioorg Med Chem Lett. 2019.
PMID: 30981576
Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).
Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW.
Patel S, et al. Among authors: kellar t.
J Med Chem. 2015 Oct 22;58(20):8182-99. doi: 10.1021/acs.jmedchem.5b01072. Epub 2015 Oct 2.
J Med Chem. 2015.
PMID: 26431428
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Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.
Link JO, Taylor JG, Xu L, Mitchell M, Guo H, Liu H, Kato D, Kirschberg T, Sun J, Squires N, Parrish J, Kellar T, Yang ZY, Yang C, Matles M, Wang Y, Wang K, Cheng G, Tian Y, Mogalian E, Mondou E, Cornpropst M, Perry J, Desai MC.
Link JO, et al. Among authors: kellar t.
J Med Chem. 2014 Mar 13;57(5):2033-46. doi: 10.1021/jm401499g. Epub 2014 Jan 10.
J Med Chem. 2014.
PMID: 24320933
Clinical Trial.
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Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection.
Link JO, Taylor JG, Xu L, Mitchell M, Guo H, Liu H, Kato D, Kirschberg T, Sun J, Squires N, Parrish J, Kellar T, Yang ZY, Yang C, Matles M, Wang Y, Wang K, Cheng G, Tian Y, Mogalian E, Mondou E, Cornpropst M, Perry J, Desai MC.
Link JO, et al. Among authors: kellar t.
J Med Chem. 2016 Aug 25;59(16):7696. doi: 10.1021/acs.jmedchem.6b01043. Epub 2016 Aug 16.
J Med Chem. 2016.
PMID: 27529494
No abstract available.
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Laparoscopic fundoplication after lung transplantation does not appear to alter lung function trajectory.
Frankel A, Kellar T, Zahir F, Chambers D, Hopkins P, Gotley D.
Frankel A, et al. Among authors: kellar t.
J Heart Lung Transplant. 2023 May;42(5):603-609. doi: 10.1016/j.healun.2022.12.001. Epub 2022 Dec 5.
J Heart Lung Transplant. 2023.
PMID: 36609090
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Multisensory stimulation for elderly with dementia: a 24-week single-blind randomized controlled pilot study.
Milev RV, Kellar T, McLean M, Mileva V, Luthra V, Thompson S, Peever L.
Milev RV, et al. Among authors: kellar t.
Am J Alzheimers Dis Other Demen. 2008 Aug-Sep;23(4):372-6. doi: 10.1177/1533317508316681. Epub 2008 May 4.
Am J Alzheimers Dis Other Demen. 2008.
PMID: 18453647
Free PMC article.
Clinical Trial.
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