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The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats.
Morley-Fletcher S, Zuena AR, Mairesse J, Gatta E, Van Camp G, Bouwalerh H, Riozzi B, Battaglia G, Pittaluga A, Olivero G, Mocaer E, Bretin S, Nicoletti F, Maccari S. Morley-Fletcher S, et al. Among authors: bretin s. Neuropharmacology. 2018 Jun;135:284-296. doi: 10.1016/j.neuropharm.2018.03.018. Epub 2018 Mar 23. Neuropharmacology. 2018. PMID: 29578034
Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and Aβ-evoked hippocampal pathology.
Monteiro-Fernandes D, Silva JM, Soares-Cunha C, Dalla C, Kokras N, Arnaud F, Billiras R, Zhuravleva V, Waites C, Bretin S, Sousa N, Sotiropoulos I. Monteiro-Fernandes D, et al. Among authors: bretin s. Mol Psychiatry. 2021 Oct;26(10):5899-5911. doi: 10.1038/s41380-020-0794-5. Epub 2020 May 28. Mol Psychiatry. 2021. PMID: 32467647
The AMPA receptor positive allosteric modulator S 47445 rescues in vivo CA3-CA1 long-term potentiation and structural synaptic changes in old mice.
Giralt A, Gómez-Climent MÁ, Alcalá R, Bretin S, Bertrand D, María Delgado-García J, Pérez-Navarro E, Alberch J, Gruart A. Giralt A, et al. Among authors: bretin s. Neuropharmacology. 2017 Sep 1;123:395-409. doi: 10.1016/j.neuropharm.2017.06.009. Epub 2017 Jun 8. Neuropharmacology. 2017. PMID: 28603025 Free article.
Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors.
Bretin S, Louis C, Seguin L, Wagner S, Thomas JY, Challal S, Rogez N, Albinet K, Iop F, Villain N, Bertrand S, Krazem A, Bérachochéa D, Billiald S, Tordjman C, Cordi A, Bertrand D, Lestage P, Danober L. Bretin S, et al. PLoS One. 2017 Sep 8;12(9):e0184429. doi: 10.1371/journal.pone.0184429. eCollection 2017. PLoS One. 2017. PMID: 28886144 Free PMC article.
A 24-week double-blind placebo-controlled study of the efficacy and safety of the AMPA modulator S47445 in patients with mild to moderate Alzheimer's disease and depressive symptoms.
Bernard K, Gouttefangeas S, Bretin S, Galtier S, Robert P, Holthoff-Detto V, Cummings J, Pueyo M. Bernard K, et al. Among authors: bretin s. Alzheimers Dement (N Y). 2019 Jun 24;5:231-240. doi: 10.1016/j.trci.2019.04.002. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31297437 Free PMC article.
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