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Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Reinicke AT, Laban K, Sachs M, Kraus V, Walden M, Damme M, Sachs W, Reichelt J, Schweizer M, Janiesch PC, Duncan KE, Saftig P, Rinschen MM, Morellini F, Meyer-Schwesinger C. Reinicke AT, et al. Among authors: sachs w, sachs m. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7963-7972. doi: 10.1073/pnas.1812413116. Epub 2019 Mar 28. Proc Natl Acad Sci U S A. 2019. PMID: 30923110 Free PMC article.
Distinct Modes of Balancing Glomerular Cell Proteostasis in Mucolipidosis Type II and III Prevent Proteinuria.
Sachs W, Sachs M, Krüger E, Zielinski S, Kretz O, Huber TB, Baranowsky A, Westermann LM, Voltolini Velho R, Ludwig NF, Yorgan TA, Di Lorenzo G, Kollmann K, Braulke T, Schwartz IV, Schinke T, Danyukova T, Pohl S, Meyer-Schwesinger C. Sachs W, et al. J Am Soc Nephrol. 2020 Aug;31(8):1796-1814. doi: 10.1681/ASN.2019090960. Epub 2020 Jul 8. J Am Soc Nephrol. 2020. PMID: 32641396 Free PMC article.
ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C. Sachs M, et al. Among authors: sachs w. J Am Soc Nephrol. 2021 Jun 1;32(6):1389-1408. doi: 10.1681/ASN.2020081213. Epub 2021 Mar 30. J Am Soc Nephrol. 2021. PMID: 33785583 Free PMC article.
Tripartite Separation of Glomerular Cell Types and Proteomes from Reporter-Free Mice.
Hatje FA, Wedekind U, Sachs W, Loreth D, Reichelt J, Demir F, Kosub C, Heintz L, Tomas NM, Huber TB, Skuza S, Sachs M, Zielinski S, Rinschen MM, Meyer-Schwesinger C. Hatje FA, et al. Among authors: sachs w. J Am Soc Nephrol. 2021 Sep;32(9):2175-2193. doi: 10.1681/ASN.2020091346. Epub 2021 Jun 1. J Am Soc Nephrol. 2021. PMID: 34074698 Free PMC article.
The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice.
Mühlig AK, Steingröver J, Heidelbach HS, Wingerath M, Sachs W, Hermans-Borgmeyer I, Meyer-Schwesinger C, Choi HY, Lim BJ, Patry C, Hoffmann GF, Endlich N, Bracke K, Weiß M, Guse AH, Lassé M, Rinschen MM, Braun F, Huber TB, Puelles VG, Schmitt CP, Oh J. Mühlig AK, et al. Among authors: sachs w. Kidney Int. 2022 Jun;101(6):1186-1199. doi: 10.1016/j.kint.2022.01.036. Epub 2022 Mar 7. Kidney Int. 2022. PMID: 35271934
Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy.
Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig A, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB. Braun F, et al. Among authors: sachs w. J Clin Invest. 2023 Jun 1;133(11):e157782. doi: 10.1172/JCI157782. J Clin Invest. 2023. PMID: 37014703 Free PMC article.
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
Reichelt J, Sachs W, Frömbling S, Fehlert J, Studencka-Turski M, Betz A, Loreth D, Blume L, Witt S, Pohl S, Brand J, Czesla M, Knop J, Florea BI, Zielinski S, Sachs M, Hoxha E, Hermans-Borgmeyer I, Zahner G, Wiech T, Krüger E, Meyer-Schwesinger C. Reichelt J, et al. Among authors: sachs w. Nat Commun. 2023 Apr 13;14(1):2114. doi: 10.1038/s41467-023-37836-8. Nat Commun. 2023. PMID: 37055432 Free PMC article.
Publisher Correction: Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
Reichelt J, Sachs W, Frömbling S, Fehlert J, Studencka-Turski M, Betz A, Loreth D, Blume L, Witt S, Pohl S, Brand J, Czesla M, Knop J, Florea BI, Zielinski S, Sachs M, Hoxha E, Hermans-Borgmeyer I, Zahner G, Wiech T, Krüger E, Meyer-Schwesinger C. Reichelt J, et al. Among authors: sachs w. Nat Commun. 2023 Apr 28;14(1):2453. doi: 10.1038/s41467-023-38206-0. Nat Commun. 2023. PMID: 37117182 Free PMC article. No abstract available.
71 results