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Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).
Owen RM, Blakemore D, Cao L, Flanagan N, Fish R, Gibson KR, Gurrell R, Huh CW, Kammonen J, Mortimer-Cassen E, Nickolls SA, Omoto K, Owen D, Pike A, Pryde DC, Reynolds DS, Roeloffs R, Rose C, Stead C, Takeuchi M, Warmus JS, Watson C. Owen RM, et al. Among authors: watson c. J Med Chem. 2019 Jun 27;62(12):5773-5796. doi: 10.1021/acs.jmedchem.9b00322. Epub 2019 Apr 26. J Med Chem. 2019. PMID: 30964988
Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.
Nickolls SA, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown AR, Stead C, Mead A, Watson C, Hsu C, Owen RM, Pike A, Fish RL, Chen L, Qiu R, Morris ED, Feng G, Whitlock M, Gorman D, van Gerven J, Reynolds DS, Dua P, Butt RP. Nickolls SA, et al. Among authors: watson c. Br J Pharmacol. 2018 Feb;175(4):708-725. doi: 10.1111/bph.14119. Epub 2018 Jan 18. Br J Pharmacol. 2018. PMID: 29214652 Free PMC article. Clinical Trial.
Optimisation of a novel series of selective CNS penetrant CB(2) agonists.
Watson C, Owen DR, Harding D, Kon-I K, Lewis ML, Mason HJ, Matsumizu M, Mukaiyama T, Rodriguez-Lens M, Shima A, Takeuchi M, Tran I, Young T. Watson C, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4284-7. doi: 10.1016/j.bmcl.2011.05.063. Epub 2011 May 25. Bioorg Med Chem Lett. 2011. PMID: 21669533
Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.
Glossop PA, Watson CA, Price DA, Bunnage ME, Middleton DS, Wood A, James K, Roberts D, Strang RS, Yeadon M, Perros-Huguet C, Clarke NP, Trevethick MA, Machin I, Stuart EF, Evans SM, Harrison AC, Fairman DA, Agoram B, Burrows JL, Feeder N, Fulton CK, Dillon BR, Entwistle DA, Spence FJ. Glossop PA, et al. Among authors: watson ca. J Med Chem. 2011 Oct 13;54(19):6888-904. doi: 10.1021/jm200884j. Epub 2011 Sep 20. J Med Chem. 2011. PMID: 21870878 Clinical Trial.
Interim 2023/2024 Season Influenza Vaccine Effectiveness in Primary and Secondary Care in the United Kingdom.
Whitaker H, Findlay B, Zitha J, Goudie R, Hassell K, Evans J, Kalapotharakou P, Agrawal U, Kele B, Hamilton M, Moore C, Byford R, Stowe J, Robertson C, Couzens A, Jamie G, Hoschler K, Pheasant K, Button E, Quinot C, Jones T, Anand S, Watson C, Andrews N, de Lusignan S, Zambon M, Williams C, Cottrell S, Marsh K, McMenamin J, Lopez Bernal J. Whitaker H, et al. Among authors: watson c. Influenza Other Respir Viruses. 2024 May;18(5):e13284. doi: 10.1111/irv.13284. Influenza Other Respir Viruses. 2024. PMID: 38773753 Free PMC article.
Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates.
Steichen JM, Phung I, Salcedo E, Ozorowski G, Willis JR, Baboo S, Liguori A, Cottrell CA, Torres JL, Madden PJ, Ma KM, Sutton HJ, Lee JH, Kalyuzhniy O, Allen JD, Rodriguez OL, Adachi Y, Mullen TM, Georgeson E, Kubitz M, Burns A, Barman S, Mopuri R, Metz A, Altheide TK, Diedrich JK, Saha S, Shields K, Schultze SE, Smith ML, Schiffner T, Burton DR, Watson CT, Bosinger SE, Crispin M, Yates JR 3rd, Paulson JC, Ward AB, Sok D, Crotty S, Schief WR. Steichen JM, et al. Among authors: watson ct. Science. 2024 May 17;384(6697):eadj8321. doi: 10.1126/science.adj8321. Epub 2024 May 17. Science. 2024. PMID: 38753769
End of 2022/23 Season Influenza Vaccine Effectiveness in Primary Care in Great Britain.
Whitaker HJ, Willam N, Cottrell S, Goudie R, Andrews N, Evans J, Moore C, Agrawal U, Hassell K, Gunson R, Zitha J, Anand S, Sebastian-Pillai P, Kalapotharakou P, Okusi C, Hoschler K, Jamie G, Kele B, Hamilton M, Couzens A, Quinot C, Pheasant K, Byford R, Marsh K, Robertson C, de Lusignan S, Williams C, Zambon M, McMenamin J, Watson CH. Whitaker HJ, et al. Among authors: watson ch. Influenza Other Respir Viruses. 2024 May;18(5):e13295. doi: 10.1111/irv.13295. Influenza Other Respir Viruses. 2024. PMID: 38744684 Free PMC article.
3,335 results