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1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.
Chrovian CC, Soyode-Johnson A, Wall JL, Rech JC, Schoellerman J, Lord B, Coe KJ, Carruthers NI, Nguyen L, Jiang X, Koudriakova T, Balana B, Letavic MA. Chrovian CC, et al. Among authors: carruthers ni. ACS Med Chem Lett. 2019 Jan 10;10(3):261-266. doi: 10.1021/acsmedchemlett.8b00542. eCollection 2019 Mar 14. ACS Med Chem Lett. 2019. PMID: 30891123 Free PMC article.
Novel human histamine H(3) receptor antagonists.
Shah C, McAtee L, Breitenbucher JG, Rudolph D, Li X, Lovenberg TW, Mazur C, Wilson SJ, Carruthers NI. Shah C, et al. Among authors: carruthers ni. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3309-12. doi: 10.1016/s0960-894x(02)00738-2. Bioorg Med Chem Lett. 2002. PMID: 12392739
The first potent and selective non-imidazole human histamine H4 receptor antagonists.
Jablonowski JA, Grice CA, Chai W, Dvorak CA, Venable JD, Kwok AK, Ly KS, Wei J, Baker SM, Desai PJ, Jiang W, Wilson SJ, Thurmond RL, Karlsson L, Edwards JP, Lovenberg TW, Carruthers NI. Jablonowski JA, et al. Among authors: carruthers ni. J Med Chem. 2003 Sep 11;46(19):3957-60. doi: 10.1021/jm0341047. J Med Chem. 2003. PMID: 12954048
Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor.
Bonaventure P, Nepomuceno D, Mazur C, Lord B, Rudolph DA, Jablonowski JA, Carruthers NI, Lovenberg TW. Bonaventure P, et al. Among authors: carruthers ni. J Pharmacol Exp Ther. 2004 Mar;308(3):1130-7. doi: 10.1124/jpet.103.060459. Epub 2003 Nov 14. J Pharmacol Exp Ther. 2004. PMID: 14617685
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C, Lord B, Gonzales L, Hoey K, Rizzolio M, Bogenstaetter M, Codd EE, Lee DH, Zhang SP, Chaplan SR, Carruthers NI. Swanson DM, et al. Among authors: carruthers ni. J Med Chem. 2005 Mar 24;48(6):1857-72. doi: 10.1021/jm0495071. J Med Chem. 2005. PMID: 15771431
Recent medicinal chemistry of the histamine H3 receptor.
Letavic MA, Barbier AJ, Dvorak CA, Carruthers NI. Letavic MA, et al. Among authors: carruthers ni. Prog Med Chem. 2006;44:181-206. doi: 10.1016/S0079-6468(05)44405-7. Prog Med Chem. 2006. PMID: 16697898 Review. No abstract available.
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
Keith JM, Gomez LA, Letavic MA, Ly KS, Jablonowski JA, Seierstad M, Barbier AJ, Wilson SJ, Boggs JD, Fraser IC, Mazur C, Lovenberg TW, Carruthers NI. Keith JM, et al. Among authors: carruthers ni. Bioorg Med Chem Lett. 2007 Feb 1;17(3):702-6. doi: 10.1016/j.bmcl.2006.10.089. Epub 2006 Nov 2. Bioorg Med Chem Lett. 2007. PMID: 17107798
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Letavic MA, Keith JM, Jablonowski JA, Stocking EM, Gomez LA, Ly KS, Miller JM, Barbier AJ, Bonaventure P, Boggs JD, Wilson SJ, Miller KL, Lord B, McAllister HM, Tognarelli DJ, Wu J, Abad MC, Schubert C, Lovenberg TW, Carruthers NI. Letavic MA, et al. Among authors: carruthers ni. Bioorg Med Chem Lett. 2007 Feb 15;17(4):1047-51. doi: 10.1016/j.bmcl.2006.11.036. Epub 2006 Nov 16. Bioorg Med Chem Lett. 2007. PMID: 17127059
96 results