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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver.
PLoS One. 2019 Feb 27;14(2):e0211568. doi: 10.1371/journal.pone.0211568. eCollection 2019.
PLoS One. 2019.
PMID: 30811418
Free PMC article.
Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.
Gavai AV, Fink BE, Fairfax DJ, Martin GS, Rossiter LM, Holst CL, Kim SH, Leavitt KJ, Mastalerz H, Han WC, Norris D, Goyal B, Swaminathan S, Patel B, Mathur A, Vyas DM, Tokarski JS, Yu C, Oppenheimer S, Zhang H, Marathe P, Fargnoli J, Lee FY, Wong TW, Vite GD.
Gavai AV, et al. Among authors: leavitt kj.
J Med Chem. 2009 Nov 12;52(21):6527-30. doi: 10.1021/jm9010065.
J Med Chem. 2009.
PMID: 19821562
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Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.
Kim SH, Tokarski JS, Leavitt KJ, Fink BE, Salvati ME, Moquin R, Obermeier MT, Trainor GL, Vite GG, Stadnick LK, Lippy JS, You D, Lorenzi MV, Chen P.
Kim SH, et al. Among authors: leavitt kj.
Bioorg Med Chem Lett. 2008 Jan 15;18(2):634-9. doi: 10.1016/j.bmcl.2007.11.076. Epub 2007 Nov 28.
Bioorg Med Chem Lett. 2008.
PMID: 18055203
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Pyrrolopyridazine MEK inhibitors.
Chen Z, Kim SH, Barbosa SA, Huynh T, Tortolani DR, Leavitt KJ, Wei DD, Manne V, Ricca CS, Gullo-Brown J, Poss MA, Vaccaro W, Salvati ME.
Chen Z, et al. Among authors: leavitt kj.
Bioorg Med Chem Lett. 2006 Feb;16(3):628-32. doi: 10.1016/j.bmcl.2005.10.052. Epub 2005 Nov 3.
Bioorg Med Chem Lett. 2006.
PMID: 16275076
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New dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Fink BE, Vite GD, Mastalerz H, Kadow JF, Kim SH, Leavitt KJ, Du K, Crews D, Mitt T, Wong TW, Hunt JT, Vyas DM, Tokarski JS.
Fink BE, et al. Among authors: leavitt kj.
Bioorg Med Chem Lett. 2005 Nov 1;15(21):4774-9. doi: 10.1016/j.bmcl.2005.07.027.
Bioorg Med Chem Lett. 2005.
PMID: 16111887
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Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).
Kim SH, Pudzianowski AT, Leavitt KJ, Barbosa J, McDonnell PA, Metzler WJ, Rankin BM, Liu R, Vaccaro W, Pitts W.
Kim SH, et al. Among authors: leavitt kj.
Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6. doi: 10.1016/j.bmcl.2004.12.016.
Bioorg Med Chem Lett. 2005.
PMID: 15686921
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