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A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes.
Phillips B, Szostak J, Titz B, Schlage WK, Guedj E, Leroy P, Vuillaume G, Martin F, Buettner A, Elamin A, Sewer A, Sierro N, Choukrallah MA, Schneider T, Ivanov NV, Teng C, Tung CK, Lim WT, Yeo YS, Vanscheeuwijck P, Peitsch MC, Hoeng J. Phillips B, et al. Among authors: martin f. Food Chem Toxicol. 2019 Apr;126:113-141. doi: 10.1016/j.fct.2019.02.008. Epub 2019 Feb 12. Food Chem Toxicol. 2019. PMID: 30763686 Free article.
Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells.
Kogel U, Gonzalez Suarez I, Xiang Y, Dossin E, Guy PA, Mathis C, Marescotti D, Goedertier D, Martin F, Peitsch MC, Hoeng J. Kogel U, et al. Among authors: martin f. Toxicol In Vitro. 2015 Dec;29(8):2102-15. doi: 10.1016/j.tiv.2015.08.004. Epub 2015 Aug 13. Toxicol In Vitro. 2015. PMID: 26277032 Free article.
Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract.
Iskandar AR, Titz B, Sewer A, Leroy P, Schneider T, Zanetti F, Mathis C, Elamin A, Frentzel S, Schlage WK, Martin F, Ivanov NV, Peitsch MC, Hoeng J. Iskandar AR, et al. Among authors: martin f. Toxicol Res (Camb). 2017 May 29;6(5):631-653. doi: 10.1039/c7tx00047b. eCollection 2017 Sep 1. Toxicol Res (Camb). 2017. PMID: 30090531 Free PMC article.
Case study: the role of mechanistic network models in systems toxicology.
Hoeng J, Talikka M, Martin F, Sewer A, Yang X, Iskandar A, Schlage WK, Peitsch MC. Hoeng J, et al. Among authors: martin f. Drug Discov Today. 2014 Feb;19(2):183-92. doi: 10.1016/j.drudis.2013.07.023. Epub 2013 Aug 9. Drug Discov Today. 2014. PMID: 23933191 Review.
Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation.
Boué S, De León H, Schlage WK, Peck MJ, Weiler H, Berges A, Vuillaume G, Martin F, Friedrichs B, Lebrun S, Meurrens K, Schracke N, Moehring M, Steffen Y, Schueller J, Vanscheeuwijck P, Peitsch MC, Hoeng J. Boué S, et al. Among authors: martin f. Toxicology. 2013 Dec 6;314(1):112-24. doi: 10.1016/j.tox.2013.09.013. Epub 2013 Oct 1. Toxicology. 2013. PMID: 24096154 Free article.
A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.
Kogel U, Schlage WK, Martin F, Xiang Y, Ansari S, Leroy P, Vanscheeuwijck P, Gebel S, Buettner A, Wyss C, Esposito M, Hoeng J, Peitsch MC. Kogel U, et al. Among authors: martin f. Food Chem Toxicol. 2014 Jun;68:204-17. doi: 10.1016/j.fct.2014.02.034. Epub 2014 Mar 12. Food Chem Toxicol. 2014. PMID: 24632068 Free article.
A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product.
Phillips B, Veljkovic E, Peck MJ, Buettner A, Elamin A, Guedj E, Vuillaume G, Ivanov NV, Martin F, Boué S, Schlage WK, Schneider T, Titz B, Talikka M, Vanscheeuwijck P, Hoeng J, Peitsch MC. Phillips B, et al. Among authors: martin f. Food Chem Toxicol. 2015 Jun;80:328-345. doi: 10.1016/j.fct.2015.03.009. Epub 2015 Apr 2. Food Chem Toxicol. 2015. PMID: 25843363 Free article.
Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe-/- Mice-An Integrative Systems Toxicology Analysis.
Titz B, Boué S, Phillips B, Talikka M, Vihervaara T, Schneider T, Nury C, Elamin A, Guedj E, Peck MJ, Schlage WK, Cabanski M, Leroy P, Vuillaume G, Martin F, Ivanov NV, Veljkovic E, Ekroos K, Laaksonen R, Vanscheeuwijck P, Peitsch MC, Hoeng J. Titz B, et al. Among authors: martin f. Toxicol Sci. 2016 Feb;149(2):441-57. doi: 10.1093/toxsci/kfv244. Epub 2015 Nov 17. Toxicol Sci. 2016. PMID: 26582801 Free PMC article.
4,465 results