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Advanced glycation end products (AGEs), but not high glucose, inhibit the osteoblastic differentiation of mouse stromal ST2 cells through the suppression of osterix expression, and inhibit cell growth and increasing cell apoptosis.
Okazaki K, Yamaguchi T, Tanaka K, Notsu M, Ogawa N, Yano S, Sugimoto T. Okazaki K, et al. Among authors: notsu m. Calcif Tissue Int. 2012 Oct;91(4):286-96. doi: 10.1007/s00223-012-9641-2. Epub 2012 Aug 18. Calcif Tissue Int. 2012. PMID: 22903508
Activation of AMP-activated protein kinase decreases receptor activator of NF-κB ligand expression and increases sclerostin expression by inhibiting the mevalonate pathway in osteocytic MLO-Y4 cells.
Yokomoto-Umakoshi M, Kanazawa I, Takeno A, Tanaka K, Notsu M, Sugimoto T. Yokomoto-Umakoshi M, et al. Among authors: notsu m. Biochem Biophys Res Commun. 2016 Jan 22;469(4):791-6. doi: 10.1016/j.bbrc.2015.12.072. Epub 2015 Dec 20. Biochem Biophys Res Commun. 2016. PMID: 26713363
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