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The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor.
Girola N, Matsuo AL, Figueiredo CR, Massaoka MH, Farias CF, Arruda DC, Azevedo RA, Monteiro HP, Resende-Lara PT, Cunha RL, Polonelli L, Travassos LR. Girola N, et al. Among authors: polonelli l. Peptides. 2016 Nov;85:1-15. doi: 10.1016/j.peptides.2016.08.006. Epub 2016 Aug 26. Peptides. 2016. PMID: 27575453
AC-1001 H3 CDR peptide induces apoptosis and signs of autophagy in vitro and exhibits antimetastatic activity in a syngeneic melanoma model.
Rabaça AN, Arruda DC, Figueiredo CR, Massaoka MH, Farias CF, Tada DB, Maia VC, Silva Junior PI, Girola N, Real F, Mortara RA, Polonelli L, Travassos LR. Rabaça AN, et al. Among authors: polonelli l. FEBS Open Bio. 2016 Jul 15;6(9):885-901. doi: 10.1002/2211-5463.12080. eCollection 2016 Sep. FEBS Open Bio. 2016. PMID: 27642552 Free PMC article.
Blockade of MIF-CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma.
Figueiredo CR, Azevedo RA, Mousdell S, Resende-Lara PT, Ireland L, Santos A, Girola N, Cunha RLOR, Schmid MC, Polonelli L, Travassos LR, Mielgo A. Figueiredo CR, et al. Among authors: polonelli l. Front Immunol. 2018 May 23;9:1132. doi: 10.3389/fimmu.2018.01132. eCollection 2018. Front Immunol. 2018. PMID: 29875777 Free PMC article.
β-Actin-binding complementarity-determining region 2 of variable heavy chain from monoclonal antibody C7 induces apoptosis in several human tumor cells and is protective against metastatic melanoma.
Arruda DC, Santos LC, Melo FM, Pereira FV, Figueiredo CR, Matsuo AL, Mortara RA, Juliano MA, Rodrigues EG, Dobroff AS, Polonelli L, Travassos LR. Arruda DC, et al. Among authors: polonelli l. J Biol Chem. 2012 Apr 27;287(18):14912-22. doi: 10.1074/jbc.M111.322362. Epub 2012 Feb 13. J Biol Chem. 2012. PMID: 22334655 Free PMC article.
Differential Antitumor Effects of IgG and IgM Monoclonal Antibodies and Their Synthetic Complementarity-Determining Regions Directed to New Targets of B16F10-Nex2 Melanoma Cells.
Dobroff AS, Rodrigues EG, Juliano MA, Friaça DM, Nakayasu ES, Almeida IC, Mortara RA, Jacysyn JF, Amarante-Mendes GP, Magliani W, Conti S, Polonelli L, Travassos LR. Dobroff AS, et al. Among authors: polonelli l. Transl Oncol. 2010 Aug 1;3(4):204-17. doi: 10.1593/tlo.09316. Transl Oncol. 2010. PMID: 20689762 Free PMC article.
Antibodies as crypts of antiinfective and antitumor peptides.
Magliani W, Conti S, Cunha RL, Travassos LR, Polonelli L. Magliani W, et al. Among authors: polonelli l. Curr Med Chem. 2009;16(18):2305-23. doi: 10.2174/092986709788453104. Curr Med Chem. 2009. PMID: 19519392 Review.
190 results