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A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE).
Machiels JP, Salazar R, Rottey S, Duran I, Dirix L, Geboes K, Wilkinson-Blanc C, Pover G, Alvis S, Champion B, Fisher K, McElwaine-Johnn H, Beadle J, Calvo E. Machiels JP, et al. Among authors: beadle j. J Immunother Cancer. 2019 Jan 28;7(1):20. doi: 10.1186/s40425-019-0510-7. J Immunother Cancer. 2019. PMID: 30691536 Free PMC article. Clinical Trial.
Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection.
Garcia-Carbonero R, Salazar R, Duran I, Osman-Garcia I, Paz-Ares L, Bozada JM, Boni V, Blanc C, Seymour L, Beadle J, Alvis S, Champion B, Calvo E, Fisher K. Garcia-Carbonero R, et al. Among authors: beadle j. J Immunother Cancer. 2017 Sep 19;5(1):71. doi: 10.1186/s40425-017-0277-7. J Immunother Cancer. 2017. PMID: 28923104 Free PMC article. Clinical Trial.
Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators.
Dyer A, Di Y, Calderon H, Illingworth S, Kueberuwa G, Tedcastle A, Jakeman P, Chia SL, Brown A, Silva MA, Barlow D, Beadle J, Hermiston T, Ferguson DJ, Champion B, Fisher KD, Seymour LW. Dyer A, et al. Among authors: beadle j. Mol Ther Oncolytics. 2016 Dec 10;4:18-30. doi: 10.1016/j.omto.2016.11.003. eCollection 2017 Mar 17. Mol Ther Oncolytics. 2016. PMID: 28345021 Free PMC article.
Espindolol for the treatment and prevention of cachexia in patients with stage III/IV non-small cell lung cancer or colorectal cancer: a randomized, double-blind, placebo-controlled, international multicentre phase II study (the ACT-ONE trial).
Stewart Coats AJ, Ho GF, Prabhash K, von Haehling S, Tilson J, Brown R, Beadle J, Anker SD; for and on behalf of the ACT‐ONE study group. Stewart Coats AJ, et al. Among authors: beadle j. J Cachexia Sarcopenia Muscle. 2016 Jun;7(3):355-65. doi: 10.1002/jcsm.12126. Epub 2016 Jul 1. J Cachexia Sarcopenia Muscle. 2016. PMID: 27386169 Free PMC article.
The ACT-ONE trial, a multicentre, randomised, double-blind, placebo-controlled, dose-finding study of the anabolic/catabolic transforming agent, MT-102 in subjects with cachexia related to stage III and IV non-small cell lung cancer and colorectal cancer: study design.
Stewart Coats AJ, Srinivasan V, Surendran J, Chiramana H, Vangipuram SR, Bhatt NN, Jain M, Shah S, Ali IA, Fuang HG, Hassan MZ, Beadle J, Tilson J, Kirwan BA, Anker SD; on behalf of the ACT-ONE Trial Investigators. Stewart Coats AJ, et al. Among authors: beadle j. J Cachexia Sarcopenia Muscle. 2011 Dec;2(4):201-207. doi: 10.1007/s13539-011-0046-2. Epub 2011 Oct 16. J Cachexia Sarcopenia Muscle. 2011. PMID: 22207908 Free PMC article.
Prevention of liver cancer cachexia-induced cardiac wasting and heart failure.
Springer J, Tschirner A, Haghikia A, von Haehling S, Lal H, Grzesiak A, Kaschina E, Palus S, Pötsch M, von Websky K, Hocher B, Latouche C, Jaisser F, Morawietz L, Coats AJ, Beadle J, Argiles JM, Thum T, Földes G, Doehner W, Hilfiker-Kleiner D, Force T, Anker SD. Springer J, et al. Among authors: beadle j. Eur Heart J. 2014 Apr;35(14):932-41. doi: 10.1093/eurheartj/eht302. Epub 2013 Aug 29. Eur Heart J. 2014. PMID: 23990596 Free PMC article.
146 results