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Small-molecule targeting of brachyury transcription factor addiction in chordoma.
Nat Med. 2019 Feb;25(2):292-300. doi: 10.1038/s41591-018-0312-3. Epub 2019 Jan 21.
Nat Med. 2019.
PMID: 30664779
Free PMC article.
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.
Sheppard HE, Dall'Agnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS, Clemons PA, Schreiber SL, Workman P, Young RA, Lin CY.
Sheppard HE, et al.
Cell Rep Med. 2021 Jan 19;2(1):100188. doi: 10.1016/j.xcrm.2020.100188. eCollection 2021 Jan 19.
Cell Rep Med. 2021.
PMID: 33521702
Free PMC article.
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Computational Drug Repositioning Identifies Potentially Active Therapies for Chordoma.
Traylor JI, Sheppard HE, Ravikumar V, Breshears J, Raza SM, Lin CY, Patel SR, DeMonte F.
Traylor JI, et al. Among authors: sheppard he.
Neurosurgery. 2021 Jan 13;88(2):428-436. doi: 10.1093/neuros/nyaa398.
Neurosurgery. 2021.
PMID: 33017025
Free PMC article.
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IRF2 is a master regulator of human keratinocyte stem cell fate.
Mercado N, Schutzius G, Kolter C, Estoppey D, Bergling S, Roma G, Gubser Keller C, Nigsch F, Salathe A, Terranova R, Reece-Hoyes J, Alford J, Russ C, Knehr J, Hoepfner D, Aebi A, Ruffner H, Beck TC, Jagannathan S, Olson CM, Sheppard HE, Elsarrag SZ, Bouwmeester T, Frederiksen M, Lohmann F, Lin CY, Kirkland S.
Mercado N, et al. Among authors: sheppard he.
Nat Commun. 2019 Oct 14;10(1):4676. doi: 10.1038/s41467-019-12559-x.
Nat Commun. 2019.
PMID: 31611556
Free PMC article.
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Democratizing clinical-genomic data: How federated platforms can promote benefits sharing in genomics.
Alvarellos M, Sheppard HE, Knarston I, Davison C, Raine N, Seeger T, Prieto Barja P, Chatzou Dunford M.
Alvarellos M, et al. Among authors: sheppard he.
Front Genet. 2023 Jan 10;13:1045450. doi: 10.3389/fgene.2022.1045450. eCollection 2022.
Front Genet. 2023.
PMID: 36704354
Free PMC article.
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