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Small-molecule targeting of brachyury transcription factor addiction in chordoma.
Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, Zhang T, Gray NS, Clarke PA, Blagg J, Workman P, Sommer J, Hornicek F, Root DE, Hahn WC, Bradner JE, Wong KK, Clemons PA, Lin CY, Kotz JD, Schreiber SL. Sharifnia T, et al. Among authors: hornicek f. Nat Med. 2019 Feb;25(2):292-300. doi: 10.1038/s41591-018-0312-3. Epub 2019 Jan 21. Nat Med. 2019. PMID: 30664779 Free PMC article.
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T. Kirsch DG, et al. Nat Med. 2007 Aug;13(8):992-7. doi: 10.1038/nm1602. Epub 2007 Aug 5. Nat Med. 2007. PMID: 17676052
Establishment and characterization of a novel chordoma cell line: CH22.
Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ. Liu X, et al. J Orthop Res. 2012 Oct;30(10):1666-73. doi: 10.1002/jor.22113. Epub 2012 Apr 13. J Orthop Res. 2012. PMID: 22504929 Free article.
Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system.
Feng Y, Sassi S, Shen JK, Yang X, Gao Y, Osaka E, Zhang J, Yang S, Yang C, Mankin HJ, Hornicek FJ, Duan Z. Feng Y, et al. J Orthop Res. 2015 Feb;33(2):199-207. doi: 10.1002/jor.22745. Epub 2014 Oct 27. J Orthop Res. 2015. PMID: 25348612 Free PMC article.
Transcriptional Profiling Supports the Notochordal Origin of Chordoma and Its Dependence on a TGFB1-TBXT Network.
Halvorsen SC, Benita Y, Hopton M, Hoppe B, Gunnlaugsson HO, Korgaonkar P, Vanderburg CR, Nielsen GP, Trepanowski N, Cheah JH, Frosch MP, Schwab JH, Rosenberg AE, Hornicek FJ, Sassi S. Halvorsen SC, et al. Am J Pathol. 2023 May;193(5):532-547. doi: 10.1016/j.ajpath.2023.01.014. Epub 2023 Feb 17. Am J Pathol. 2023. PMID: 36804377 Free article.
Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.
Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, Harmon D, Raskin K, Yang C, Mankin H, Springfield D, Hornicek F, Duan Z. Schwab J, et al. Among authors: hornicek f. Anticancer Res. 2009 Jun;29(6):1867-71. Anticancer Res. 2009. PMID: 19528441 Free article.
418 results