Gretler DD - Search Results

1

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease.

Howard J, Hemmaway CJ, Telfer P, Layton DM, Porter J, Awogbade M, Mant T, Gretler DD, Dufu K, Hutchaleelaha A, Patel M, Siu V, Dixon S, Landsman N, Tonda M, Lehrer-Graiwer J. Howard J, et al. Among authors: gretler dd. Blood. 2019 Apr 25;133(17):1865-1875. doi: 10.1182/blood-2018-08-868893. Epub 2019 Jan 17. Blood. 2019. PMID: 30655275 Free PMC article. Clinical Trial.

2

Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease.

Hutchaleelaha A, Patel M, Washington C, Siu V, Allen E, Oksenberg D, Gretler DD, Mant T, Lehrer-Graiwer J. Hutchaleelaha A, et al. Among authors: gretler dd. Br J Clin Pharmacol. 2019 Jun;85(6):1290-1302. doi: 10.1111/bcp.13896. Epub 2019 Mar 31. Br J Clin Pharmacol. 2019. PMID: 30743314 Free PMC article. Clinical Trial.

3

First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers.

Fox JC, Hellawell JL, Rao S, O'Reilly T, Lumpkin R, Jernelius J, Gretler D, Sinha U. Fox JC, et al. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129. doi: 10.1002/cpdd.700. Epub 2019 Jun 6. Clin Pharmacol Drug Dev. 2020. PMID: 31172685 Free PMC article. Clinical Trial.

4

PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers.

Coffey G, Rani A, Betz A, Pak Y, Haberstock-Debic H, Pandey A, Hollenbach S, Gretler DD, Mant T, Jurcevic S, Sinha U. Coffey G, et al. Among authors: gretler dd. J Clin Pharmacol. 2017 Feb;57(2):194-210. doi: 10.1002/jcph.794. Epub 2016 Aug 17. J Clin Pharmacol. 2017. PMID: 27406873 Free PMC article.

5

Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study.

Morganroth J, Gretler DD, Hollenbach SJ, Lambing JL, Sinha U. Morganroth J, et al. Among authors: gretler dd. Expert Opin Pharmacother. 2013 Jan;14(1):5-13. doi: 10.1517/14656566.2013.753057. Epub 2012 Dec 10. Expert Opin Pharmacother. 2013. PMID: 23216423 Clinical Trial.

6

Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa).

Connolly SJ, Eikelboom J, Dorian P, Hohnloser SH, Gretler DD, Sinha U, Ezekowitz MD. Connolly SJ, et al. Among authors: gretler dd. Eur Heart J. 2013 May;34(20):1498-505. doi: 10.1093/eurheartj/eht039. Epub 2013 Mar 13. Eur Heart J. 2013. PMID: 23487517 Free PMC article. Clinical Trial.

7

A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT).

Turpie AG, Bauer KA, Davidson BL, Fisher WD, Gent M, Huo MH, Sinha U, Gretler DD; EXPERT Study Group. Turpie AG, et al. Among authors: gretler dd. Thromb Haemost. 2009 Jan;101(1):68-76. Thromb Haemost. 2009. PMID: 19132191 Clinical Trial.

8

Pharmacokinetic and pharmacodynamic properties of eptifabatide in healthy subjects receiving unfractionated heparin or the low-molecular-weight heparin enoxaparin.

Gretler DD. Gretler DD. Clin Ther. 2003 Oct;25(10):2564-74. doi: 10.1016/s0149-2918(03)80317-x. Clin Ther. 2003. PMID: 14667957 Clinical Trial.

9

Influence of diuretic therapy on the clonidine suppression test.

Gretler DD, Gramelspacher GP, Fumo MT, Elliott WJ, Murphy MB. Gretler DD, et al. J Clin Pharmacol. 1991 May;31(5):448-54. doi: 10.1002/j.1552-4604.1991.tb01902.x. J Clin Pharmacol. 1991. PMID: 2050831 Clinical Trial.

10

A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: the INNOVATE-PCI trial.

Welsh RC, Rao SV, Zeymer U, Thompson VP, Huber K, Kochman J, McClure MW, Gretler DD, Bhatt DL, Gibson CM, Angiolillo DJ, Gurbel PA, Berdan LG, Paynter G, Leonardi S, Madan M, French WJ, Harrington RA; INNOVATE-PCI Investigators. Welsh RC, et al. Among authors: gretler dd. Circ Cardiovasc Interv. 2012 Jun;5(3):336-46. doi: 10.1161/CIRCINTERVENTIONS.111.964197. Epub 2012 May 29. Circ Cardiovasc Interv. 2012. PMID: 22647518 Clinical Trial.

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