de Koning HP - Search Results

1

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs.

Nnadi CO, Ebiloma GU, Black JA, Nwodo NJ, Lemgruber L, Schmidt TJ, de Koning HP. Nnadi CO, et al. Among authors: de koning hp. Molecules. 2019 Jan 12;24(2):268. doi: 10.3390/molecules24020268. Molecules. 2019. PMID: 30642032 Free PMC article.

2

Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals.

De Koning HP. De Koning HP. Mol Pharmacol. 2001 Mar;59(3):586-92. doi: 10.1124/mol.59.3.586. Mol Pharmacol. 2001. PMID: 11179454

3

Transporters in African trypanosomes: role in drug action and resistance.

de Koning HP. de Koning HP. Int J Parasitol. 2001 May 1;31(5-6):512-22. doi: 10.1016/s0020-7519(01)00167-9. Int J Parasitol. 2001. PMID: 11334936 Review.

4

The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.

de Koning HP, Anderson LF, Stewart M, Burchmore RJ, Wallace LJ, Barrett MP. de Koning HP, et al. Antimicrob Agents Chemother. 2004 May;48(5):1515-9. doi: 10.1128/AAC.48.5.1515-1519.2004. Antimicrob Agents Chemother. 2004. PMID: 15105099 Free PMC article.

5

A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.

Anene BM, Ezeokonkwo RC, Mmesirionye TI, Tettey JN, Brock JM, Barrett MP, De Koning HP. Anene BM, et al. Among authors: de koning hp. Parasitology. 2006 Jan;132(Pt 1):127-33. doi: 10.1017/S0031182005008760. Parasitology. 2006. PMID: 16393361

6

Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.

Bridges DJ, Gould MK, Nerima B, Mäser P, Burchmore RJ, de Koning HP. Bridges DJ, et al. Among authors: de koning hp. Mol Pharmacol. 2007 Apr;71(4):1098-108. doi: 10.1124/mol.106.031351. Epub 2007 Jan 18. Mol Pharmacol. 2007. PMID: 17234896

7

Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes.

de Koning HP. de Koning HP. Trends Parasitol. 2008 Aug;24(8):345-9. doi: 10.1016/j.pt.2008.04.006. Epub 2008 Jul 1. Trends Parasitol. 2008. PMID: 18599351

8

Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes.

Stewart ML, Burchmore RJ, Clucas C, Hertz-Fowler C, Brooks K, Tait A, Macleod A, Turner CM, De Koning HP, Wong PE, Barrett MP. Stewart ML, et al. Among authors: de koning hp. Eukaryot Cell. 2010 Feb;9(2):336-43. doi: 10.1128/EC.00200-09. Epub 2009 Dec 4. Eukaryot Cell. 2010. PMID: 19966032 Free PMC article.

9

A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes.

Ward CP, Burgess KE, Burchmore RJ, Barrett MP, de Koning HP. Ward CP, et al. Among authors: de koning hp. Mol Biochem Parasitol. 2010 Dec;174(2):145-9. doi: 10.1016/j.molbiopara.2010.07.002. Epub 2010 Jul 15. Mol Biochem Parasitol. 2010. PMID: 20637807

10

Symmetrical choline-derived dications display strong anti-kinetoplastid activity.

Ibrahim HM, Al-Salabi MI, El Sabbagh N, Quashie NB, Alkhaldi AA, Escale R, Smith TK, Vial HJ, de Koning HP. Ibrahim HM, et al. Among authors: de koning hp. J Antimicrob Chemother. 2011 Jan;66(1):111-25. doi: 10.1093/jac/dkq401. Epub 2010 Nov 14. J Antimicrob Chemother. 2011. PMID: 21078603 Free PMC article.

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