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Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function.
Cerniauskas E, Kurzawa-Akanbi M, Xie L, Hallam D, Moya-Molina M, White K, Steel D, Doherty M, Whitfield P, Al-Aama J, Armstrong L, Kavanagh D, Lambris JD, Korolchuk VI, Harris C, Lako M. Cerniauskas E, et al. Among authors: kurzawa akanbi m. Stem Cells Transl Med. 2020 Dec;9(12):1585-1603. doi: 10.1002/sctm.20-0211. Epub 2020 Aug 20. Stem Cells Transl Med. 2020. PMID: 32815311 Free PMC article.
Age-related macular degeneration - biomarkers and therapies.
Kurzawa-Akanbi M, Lotery A, Steel DH, Lako M. Kurzawa-Akanbi M, et al. Regen Med. 2021 May;16(5):431-434. doi: 10.2217/rme-2021-0059. Epub 2021 May 19. Regen Med. 2021. PMID: 34008416 Free article. No abstract available.
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.
Kurzawa-Akanbi M, Tammireddy S, Fabrik I, Gliaudelytė L, Doherty MK, Heap R, Matečko-Burmann I, Burmann BM, Trost M, Lucocq JM, Gherman AV, Fairfoul G, Singh P, Burté F, Green A, McKeith IG, Härtlova A, Whitfield PD, Morris CM. Kurzawa-Akanbi M, et al. Acta Neuropathol. 2021 Dec;142(6):961-984. doi: 10.1007/s00401-021-02367-3. Epub 2021 Sep 13. Acta Neuropathol. 2021. PMID: 34514546 Free PMC article.
Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance.
Pfeffer G, Gorman GS, Griffin H, Kurzawa-Akanbi M, Blakely EL, Wilson I, Sitarz K, Moore D, Murphy JL, Alston CL, Pyle A, Coxhead J, Payne B, Gorrie GH, Longman C, Hadjivassiliou M, McConville J, Dick D, Imam I, Hilton D, Norwood F, Baker MR, Jaiser SR, Yu-Wai-Man P, Farrell M, McCarthy A, Lynch T, McFarland R, Schaefer AM, Turnbull DM, Horvath R, Taylor RW, Chinnery PF. Pfeffer G, et al. Brain. 2014 May;137(Pt 5):1323-36. doi: 10.1093/brain/awu060. Epub 2014 Apr 10. Brain. 2014. PMID: 24727571 Free PMC article.
Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.
Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF. Wei W, et al. Acta Neuropathol Commun. 2017 Feb 2;5(1):13. doi: 10.1186/s40478-016-0404-6. Acta Neuropathol Commun. 2017. PMID: 28153046 Free PMC article.
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