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Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.
Nonomura K, Lukacs V, Sweet DT, Goddard LM, Kanie A, Whitwam T, Ranade SS, Fujimori T, Kahn ML, Patapoutian A. Nonomura K, et al. Among authors: kahn ml. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12817-12822. doi: 10.1073/pnas.1817070115. Epub 2018 Nov 27. Proc Natl Acad Sci U S A. 2018. PMID: 30482854 Free PMC article.
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.
Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML. Schmaier AA, et al. Among authors: kahn ml. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21167-72. doi: 10.1073/pnas.0906436106. Epub 2009 Nov 25. Proc Natl Acad Sci U S A. 2009. PMID: 19940238 Free PMC article.
Blood flow reprograms lymphatic vessels to blood vessels.
Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, Stachelek SJ, Srinivasan S, Guo L, Vicente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn ML. Chen CY, et al. Among authors: kahn ml. J Clin Invest. 2012 Jun;122(6):2006-17. doi: 10.1172/JCI57513. Epub 2012 May 24. J Clin Invest. 2012. PMID: 22622036 Free PMC article.
Lymph flow regulates collecting lymphatic vessel maturation in vivo.
Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML. Sweet DT, et al. Among authors: kahn ml. J Clin Invest. 2015 Aug 3;125(8):2995-3007. doi: 10.1172/JCI79386. Epub 2015 Jul 27. J Clin Invest. 2015. PMID: 26214523 Free PMC article.
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.
Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML. Zhou Z, et al. Among authors: kahn ml. Nature. 2016 Apr 7;532(7597):122-6. doi: 10.1038/nature17178. Epub 2016 Mar 30. Nature. 2016. PMID: 27027284 Free PMC article.
A BMPy Road for Venous Development.
Goddard LM, Kahn ML. Goddard LM, et al. Among authors: kahn ml. Dev Cell. 2017 Sep 11;42(5):435-436. doi: 10.1016/j.devcel.2017.08.016. Dev Cell. 2017. PMID: 28898672 Free article.
Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.
Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML. Goddard LM, et al. Among authors: kahn ml. Dev Cell. 2017 Nov 6;43(3):274-289.e5. doi: 10.1016/j.devcel.2017.09.023. Epub 2017 Oct 19. Dev Cell. 2017. PMID: 29056552 Free PMC article.
250 results