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Page 1
Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice.
Griñán-Ferré C, Vasilopoulou F, Abás S, Rodríguez-Arévalo S, Bagán A, Sureda FX, Pérez B, Callado LF, García-Sevilla JA, García-Fuster MJ, Escolano C, Pallàs M. Griñán-Ferré C, et al. Among authors: perez b. Neurotherapeutics. 2019 Apr;16(2):416-431. doi: 10.1007/s13311-018-00681-5. Neurotherapeutics. 2019. PMID: 30460457 Free PMC article.
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Pérez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaró A, Bartolini M, De Simone A, Andrisano V, Pérez B, Sabate R, Sureda FX, Vázquez S, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: perez b. Eur J Med Chem. 2019 Oct 15;180:613-626. doi: 10.1016/j.ejmech.2019.07.051. Epub 2019 Jul 17. Eur J Med Chem. 2019. PMID: 31351393 Free article.
Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.
Aragó M, Moreno-Felici J, Abás S, Rodríguez-Arévalo S, Hyroššová P, Figueras A, Viñals F, Pérez B, Loza MI, Brea J, Latorre P, Carrodeguas JA, García-Rovés PM, Galdeano C, Ginex T, Luque FJ, Escolano C, Perales JC. Aragó M, et al. Among authors: perez b. Biomed Pharmacother. 2020 Jan;121:109601. doi: 10.1016/j.biopha.2019.109601. Epub 2019 Nov 15. Biomed Pharmacother. 2020. PMID: 31739159 Free article.
Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease.
Abás S, Rodríguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Brocos-Mosquera I, Muguruza C, Pérez B, Molins E, Luque FJ, Pérez-Lozano P, de Jonghe S, Daelemans D, Naesens L, Brea J, Loza MI, Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ, Radan M, Djikic T, Nikolic K, Pallàs M, Callado LF, Escolano C. Abás S, et al. Among authors: perez lozano p, perez b. J Med Chem. 2020 Apr 9;63(7):3610-3633. doi: 10.1021/acs.jmedchem.9b02080. Epub 2020 Mar 19. J Med Chem. 2020. PMID: 32150414
Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease.
Griñán-Ferré C, Codony S, Pujol E, Yang J, Leiva R, Escolano C, Puigoriol-Illamola D, Companys-Alemany J, Corpas R, Sanfeliu C, Pérez B, Loza MI, Brea J, Morisseau C, Hammock BD, Vázquez S, Pallàs M, Galdeano C. Griñán-Ferré C, et al. Among authors: perez b. Neurotherapeutics. 2020 Oct;17(4):1825-1835. doi: 10.1007/s13311-020-00854-1. Neurotherapeutics. 2020. PMID: 32488482 Free PMC article.
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.
Pérez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaró A, Ginex T, Sabate R, Pérez B, Andrisano V, Puigoriol-Illamola D, Pallàs M, Luque FJ, Loza MI, Brea J, Ferrer I, Ciruela F, Messeguer A, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: perez b. J Med Chem. 2020 Sep 10;63(17):9360-9390. doi: 10.1021/acs.jmedchem.0c00528. Epub 2020 Aug 11. J Med Chem. 2020. PMID: 32706255
Correction to Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease.
Abás S, Rodríguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Brocos-Mosquera I, Muguruza C, Pérez B, Molins E, Luque FJ, Pérez-Lozano P, de Jonghe S, Daelemans D, Naesens L, Brea J, Loza MI, Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ, Radan M, Djikic T, Nikolic K, Pallàs M, Callado LF, Escolano C. Abás S, et al. Among authors: perez lozano p, perez b. J Med Chem. 2020 Sep 24;63(18):10529. doi: 10.1021/acs.jmedchem.0c01324. Epub 2020 Sep 14. J Med Chem. 2020. PMID: 32924503 No abstract available.
Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease.
Rodriguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Pallàs M, Brocos-Mosquera I, Callado LF, Loza MI, Martínez AL, Brea J, Pérez B, Molins E, De Jonghe S, Daelemans D, Radan M, Djikic T, Nikolic K, Hernández-Hernández E, García-Fuster MJ, García-Sevilla JA, Escolano C. Rodriguez-Arévalo S, et al. Among authors: perez b. Eur J Med Chem. 2021 Oct 15;222:113540. doi: 10.1016/j.ejmech.2021.113540. Epub 2021 May 20. Eur J Med Chem. 2021. PMID: 34118720 Free article.
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Pont C, Ginex T, Griñán-Ferré C, Scheiner M, Mattellone A, Martínez N, Arce EM, Soriano-Fernández Y, Naldi M, De Simone A, Barenys M, Gómez-Catalán J, Pérez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallàs M, Luque FJ, Muñoz-Torrero D. Pont C, et al. Among authors: perez b. Eur J Med Chem. 2021 Dec 5;225:113779. doi: 10.1016/j.ejmech.2021.113779. Epub 2021 Aug 16. Eur J Med Chem. 2021. PMID: 34418785 Free article.
914 results