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Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke.
Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN Jr, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV; NeuroNEXT Clinical Trials Network NN104 Investigators. Lyden P, et al. Among authors: zlokovic bv. Ann Neurol. 2019 Jan;85(1):125-136. doi: 10.1002/ana.25383. Epub 2019 Jan 7. Ann Neurol. 2019. PMID: 30450637 Free PMC article. Clinical Trial.
Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background.
Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. Tabrizi P, et al. Among authors: zlokovic bv. Arterioscler Thromb Vasc Biol. 1999 Nov;19(11):2801-6. doi: 10.1161/01.atv.19.11.2801. Arterioscler Thromb Vasc Biol. 1999. PMID: 10559029
Activated protein C and ischemic stroke.
Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. Griffin JH, et al. Among authors: zlokovic bv. Crit Care Med. 2004 May;32(5 Suppl):S247-53. doi: 10.1097/01.ccm.0000126127.87484.2b. Crit Care Med. 2004. PMID: 15118526 Review.
334 results