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A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma.
Cancer Res. 2018 Nov 15;78(22):6509-6522. doi: 10.1158/0008-5472.CAN-18-1697. Epub 2018 Oct 2.
Cancer Res. 2018.
PMID: 30279244
Free article.
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, McKinnon H, McMenemy C, Mezna M, Morrice NA, Munro J, Naylor G, Rath N, Schüttelkopf AW, Sime M, Olson MF.
Unbekandt M, et al. Among authors: konczal j.
Cancer Res. 2018 Apr 15;78(8):2096-2114. doi: 10.1158/0008-5472.CAN-17-2870. Epub 2018 Jan 30.
Cancer Res. 2018.
PMID: 29382705
Free PMC article.
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Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Francis S, Croft D, Schüttelkopf AW, Parry C, Pugliese A, Cameron K, Claydon S, Drysdale M, Gardner C, Gohlke A, Goodwin G, Gray CH, Konczal J, McDonald L, Mezna M, Pannifer A, Paul NR, Machesky L, McKinnon H, Bower J.
Francis S, et al. Among authors: konczal j.
Bioorg Med Chem Lett. 2019 Apr 15;29(8):1023-1029. doi: 10.1016/j.bmcl.2019.01.035. Epub 2019 Jan 30.
Bioorg Med Chem Lett. 2019.
PMID: 30773430
Free PMC article.
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A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB.
Gray CH, Konczal J, Mezna M, Ismail S, Bower J, Drysdale M.
Gray CH, et al. Among authors: konczal j.
Protein Expr Purif. 2017 Apr;132:75-84. doi: 10.1016/j.pep.2017.01.010. Epub 2017 Jan 28.
Protein Expr Purif. 2017.
PMID: 28137655
Free PMC article.
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Streamlining workflow and automation to accelerate laboratory scale protein production.
Konczal J, Gray CH.
Konczal J, et al.
Protein Expr Purif. 2017 May;133:160-169. doi: 10.1016/j.pep.2017.03.016. Epub 2017 Mar 19.
Protein Expr Purif. 2017.
PMID: 28330825
Free article.
Review.
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Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli.
Konczal J, Bower J, Gray CH.
Konczal J, et al.
PLoS One. 2019 Apr 23;14(4):e0215892. doi: 10.1371/journal.pone.0215892. eCollection 2019.
PLoS One. 2019.
PMID: 31013332
Free PMC article.
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