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Long-term exposure to extremely low-dose of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induce non-malignant breast epithelial cell transformation through activation of the a9-nicotinic acetylcholine receptor-mediated signaling pathway.
Fararjeh AS, Tu SH, Chen LC, Cheng TC, Liu YR, Chang HL, Chang HW, Huang CC, Wang HR, Hwang-Verslues WW, Wu CH, Ho YS. Fararjeh AS, et al. Among authors: wu ch. Environ Toxicol. 2019 Jan;34(1):73-82. doi: 10.1002/tox.22659. Epub 2018 Sep 26. Environ Toxicol. 2019. PMID: 30259641
Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation.
Ho YS, Chen CH, Wang YJ, Pestell RG, Albanese C, Chen RJ, Chang MC, Jeng JH, Lin SY, Liang YC, Tseng H, Lee WS, Lin JK, Chu JS, Chen LC, Lee CH, Tso WL, Lai YC, Wu CH. Ho YS, et al. Among authors: wu ch. Toxicol Appl Pharmacol. 2005 Jun 1;205(2):133-48. doi: 10.1016/j.taap.2004.09.019. Epub 2005 Jan 8. Toxicol Appl Pharmacol. 2005. PMID: 15893541
Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells.
Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS. Lee CH, et al. Among authors: wu ch. Breast Cancer Res Treat. 2011 Sep;129(2):331-45. doi: 10.1007/s10549-010-1209-0. Epub 2010 Oct 16. Breast Cancer Res Treat. 2011. PMID: 20953833
3,846 results