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An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice.
Edderkaoui M, Chheda C, Soufi B, Zayou F, Hu RW, Ramanujan VK, Pan X, Boros LG, Tajbakhsh J, Madhav A, Bhowmick NA, Wang Q, Lewis M, Tuli R, Habtezion A, Murali R, Pandol SJ. Edderkaoui M, et al. Gastroenterology. 2018 Dec;155(6):1985-1998.e5. doi: 10.1053/j.gastro.2018.08.028. Epub 2018 Aug 23. Gastroenterology. 2018. PMID: 30144430 Free PMC article.
Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase.
Edderkaoui M, Hong P, Vaquero EC, Lee JK, Fischer L, Friess H, Buchler MW, Lerch MM, Pandol SJ, Gukovskaya AS. Edderkaoui M, et al. Am J Physiol Gastrointest Liver Physiol. 2005 Dec;289(6):G1137-47. doi: 10.1152/ajpgi.00197.2005. Epub 2005 Jul 21. Am J Physiol Gastrointest Liver Physiol. 2005. PMID: 16037546 Free article.
48 results