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Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease.
Igaki K, Nakamura Y, Tanaka M, Mizuno S, Yoshimatsu Y, Komoike Y, Uga K, Shibata A, Imaichi H, Takayuki S, Ishimura Y, Yamasaki M, Kanai T, Tsukimi Y, Tsuchimori N. Igaki K, et al. Among authors: ishimura y. Inflamm Res. 2019 Jun;68(6):493-509. doi: 10.1007/s00011-019-01234-y. Epub 2019 Apr 10. Inflamm Res. 2019. PMID: 30972425
Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn's Disease.
Gamo K, Okuzono Y, Yabuki M, Ochi T, Sugimura K, Sato Y, Sagara M, Hayashi H, Ishimura Y, Nishimoto Y, Murakawa Y, Shiokawa Z, Gotoh M, Miyazaki T, Ebisuno Y. Gamo K, et al. Among authors: ishimura y. Inflamm Bowel Dis. 2018 May 18;24(6):1251-1265. doi: 10.1093/ibd/izy079. Inflamm Bowel Dis. 2018. PMID: 29669006 Free PMC article.
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Tanaka Y, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y, Kondo S, Miyamoto M, Nishihara M, Ishimura Y, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: ishimura y. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17. doi: 10.1016/j.bmc.2012.07.034. Epub 2012 Jul 27. Bioorg Med Chem. 2012. PMID: 22898254
Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives.
Niida A, Kanematsu-Yamaki Y, Asakawa T, Ishimura Y, Fujita H, Matsumiya K, Nishizawa N, Adachi Y, Mochida T, Tsuchimori K, Yoneyama-Hirozane M, Sakamoto J, Hirabayashi H, Fukui H, Takekawa S, Asami T. Niida A, et al. Among authors: ishimura y. Bioorg Med Chem. 2018 Feb 1;26(3):566-572. doi: 10.1016/j.bmc.2017.12.014. Epub 2017 Dec 8. Bioorg Med Chem. 2018. PMID: 29279243
Salivary mucocele in a laboratory beagle.
Yasuno H, Nagai H, Ishimura Y, Watanabe T, Yamasaki H, Anayama H, Takai Y, Yamauchi H, Hara Y, Murai F, Kandori H. Yasuno H, et al. Among authors: ishimura y. J Toxicol Pathol. 2011 Jun;24(2):131-5. doi: 10.1293/tox.24.131. Epub 2011 Jun 30. J Toxicol Pathol. 2011. PMID: 22272052 Free PMC article.
238 results